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POGLUT1 Antibodies
AND POGLUT1 ELISA kits, POGLUT1 Proteins
Many biological assays use antibodies to detect POGLUT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POGLUT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POGLUT1 antibodies...
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POGLUT1 Overview
Facts about Protein O-glucosyltransferase 1.
Protein O-glucosyltransferase 1 (POGLUT1)
Dual specificity glycosyltransferase that catalyzes the transport of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076). Specifically targets extracellular EGF repeats of protein like CRB2, F7, F9 and NOTCH2 (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076).
Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, contributing to modulate muscle growth (PubMed:27807076). Notch glucosylation doesn't affect Notch ligand binding (PubMed:21490058).
Gene Information
| Human | |
|---|---|
| Gene Name: | POGLUT1 |
| Uniprot: | Q8NBL1 |
| Entrez: | 56983 |
Family
| Belongs to: |
|---|
| glycosyltransferase 90 family |
Alternative Names
9630046K23Rik; C3orf9; CAP10-like protein, 46 kDa; chromosome 3 open reading frame 9; CLP46; EC 2.4.1.-; hCLP46CAP10-like 46 kDa protein; KDELC family like 1; KDELCL1; KTEL (Lys-Tyr-Glu-Leu) containing 1; KTEL motif-containing protein 1; KTELC1; MDS010; MDSRP; MDSRPKTELC1; MGC32995; Myelodysplastic syndromes relative protein; POGLUT1; protein O-glucosyltransferase 1; Rumi; x 010 protein
Molecular Weight
Mass (kDA):
46.189 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q13.33 |
| Sequence: | 3; NC_000003.12 (119468955..119494708) |
Tissue Specificity
Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. Expressed in the epidermis, especially in the upper parts, stratum spinosum and stratum granulosum (at protein level).
Subcellular Localizations
Endoplasmic reticulum lumen.
Diseases
- Leukemia
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia
- Dysmyelopoietic Syndromes
- Refractory Anaemia With Excess Blasts
- Refractory Anemia With Excess Blasts In Transformation
- Acute Lymphocytic Leukemia
- Precursor T-cell Lymphoblastic Leukemia-lymphoma
- Retinoblastoma
Pathways
- Cell Proliferation
- Pathogenesis
- Notch Signaling Pathway
- Rna Interference
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POGLUT1
bosterbio.com/bosterbio-gene-info-cards/POGLUT1
References
PMID: 16524674 by Teng Y., et al. Cloning, expression and characterization of a novel human CAP10-like gene hCLP46 from CD34+ stem/progenitor cells.
PMID: 21490058 by Fernandez-Valdivia R., et al. Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi.