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POFUT2 Antibodies
AND POFUT2 ELISA kits, POFUT2 Proteins
Many biological assays use antibodies to detect POFUT2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POFUT2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POFUT2 antibodies...
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POFUT2 Infographic by Boster Bio
All POFUT2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, WB
$523
Cat # M08299
100 µl
Cat # M08299
100 µl
POFUT2 Overview
Facts about GDP-fucose protein O-fucosyltransferase 2.
GDP-fucose protein O-fucosyltransferase 2 (POFUT2)
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families such as the ADAMTS family, the thrombosporin (TSP) and spondin families.
The O-fucosylation of TSRs can also be required for restricting epithelial to mesenchymal transition (EMT), keeping the right patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13.
Gene Information
| Human | |
|---|---|
| Gene Name: | POFUT2 |
| Uniprot: | Q9Y2G5 |
| Entrez: | 23275 |
Family
| Belongs to: |
|---|
| glycosyltransferase 68 family |
Alternative Names
C21orf80; chromosome 21 open reading frame 80; FUT13EC 2.4.1.221; GDP-fucose protein O-fucosyltransferase 2; KIAA0958; O-FucT-2; Peptide-O-fucosyltransferase 2; protein O-fucosyltransferase 2
Molecular Weight
Mass (kDA):
49.976 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.3 |
| Sequence: | 21; NC_000021.9 (45263928..45287914, complement) |
Tissue Specificity
Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver and fetal heart.
Subcellular Localizations
Endoplasmic reticulum. Golgi apparatus. Mainly located in the endoplasmic reticulum.
Diseases
- Teratoma
- Glioma
- Glioblastoma
- Malignant Paraganglionic Neoplasm
- Down Syndrome
- Aneuploidy
- Malignant Glioma
- Brain Neoplasms
- Purpura, Thrombotic Thrombocytopenic
- Purpura
- Tumor Angiogenesis
Pathways
- Glycosylation
- Localization
- Fucosylation
- Secretion
- Protein O-linked Fucosylation
- Gastrulation
- Epithelial To Mesenchymal Transition
- Cell Motility
- Angiogenesis
PTMs
- Glycosylation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POFUT2
bosterbio.com/bosterbio-gene-info-cards/POFUT2
References
PMID: 15233996 by Menzel O., et al. The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development.
PMID: 12966037 by Martinez-Duncker I., et al. A new superfamily of protein-O-fucosyltransferases, alpha2- fucosyltransferases, and alpha6-fucosyltransferases: phylogeny and identification of conserved peptide motifs.