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PNPLA3 Antibodies
AND PNPLA3 ELISA kits, PNPLA3 Proteins
Many biological assays use antibodies to detect PNPLA3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PNPLA3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PNPLA3 antibodies...
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PNPLA3 Overview
Facts about 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3.
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3)
Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Doesn't esterify other lysophospholipids.
Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally owns low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a part in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221).
Gene Information
| Human | |
|---|---|
| Gene Name: | PNPLA3 |
| Uniprot: | Q9NST1 |
| Entrez: | 80339 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Acylglycerol O-acyltransferase; Adiponutrin; ADPN; ADPNdJ796I17.1; C22orf20; Calcium-independent phospholipase A2-epsilon; chromosome 22 open reading frame 20; EC 2.3.1.-; EC 2.7.7.56; EC 3.1.1.3; EC 4.2.3.4; FLJ22012; iPLA(2)epsilon; iPLA2-epsilon; patatin-like phospholipase domain containing 3; patatin-like phospholipase domain-containing protein 3; PNPLA3
Molecular Weight
Mass (kDA):
52.865 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.31 |
| Sequence: | 22; NC_000022.11 (43923805..43947582) |
Subcellular Localizations
Membrane; Single-pass type II membrane protein. Lipid droplet.
Diseases
- Fatty Liver
- Liver Diseases
- Nonalcoholic Fatty Liver Disease
- Steatosis
- Obesity
- Steatohepatitis
- Liver Cirrhosis
- Insulin Resistance
- Fibrosis
- Hepatitis
- Hepatitis C
- Liver Damage
- Diabetes Mellitus
Pathways
- Pathogenesis
- Transport
- Secretion
- Parturition
- Insulin Secretion
- Dna Methylation
- Localization
- Liver Development
- Inflammatory Response
- Glucose Homeostasis
- Methylation
- Lipid Oxidation
- Chemotaxis
PTMs
- Phosphorylation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PNPLA3
bosterbio.com/bosterbio-gene-info-cards/PNPLA3
References
PMID: 12529303 by Collins J.E., et al. Reevaluating human gene annotation: a second-generation analysis of chromosome 22.
PMID: 15364929 by Jenkins C.M., et al. Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.