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Melanocyte protein PMEL Antibodies
AND PMEL ELISA kits, Melanocyte protein PMEL Proteins
Many biological assays use antibodies to detect Melanocyte protein PMEL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Melanocyte protein PMEL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Melanocyte protein PMEL antibodies...
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PMEL Infographic by Boster Bio
All PMEL Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$370
Cat # A01262-1
100 μg/vial
Cat # A01262-1
100 μg/vial
Human
Flow Cytometry, IF
$523
Cat # M01262-2
100 µl
Cat # M01262-2
100 µl
Dog, Human, Monkey, Rat
IF, IHC, WB
$523
Cat # M01262-1
100 µl
Cat # M01262-1
100 µl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A01262-3
100 µg/vial
Cat # A01262-3
100 µg/vial
PMEL Overview
Facts about Melanocyte protein PMEL.
Melanocyte protein PMEL (PMEL)
Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II.
The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the look within of different fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.
Gene Information
| Human | |
|---|---|
| Gene Name: | PMEL |
| Uniprot: | P40967 |
| Entrez: | 6490 |
Family
| Belongs to: |
|---|
| PMEL/NMB family |
Alternative Names
D12S53EP1; gp100; ME20; ME20-M; melanocyte protein mel 17; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; melanosomal matrix protein17; PMEL17P100; premelanosome proteinME20M; SI; SIL; silver (mouse homolog) like; silver homolog (mouse); Silver locus protein homolog; silver, mouse, homolog of; SILVPmel17
Molecular Weight
Mass (kDA):
70.255 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.2 |
| Sequence: | 12; NC_000012.12 (55954105..55966712, complement) |
Tissue Specificity
Preferentially expressed in melanomas. Some expression was found in dysplastic nevi. Not found in normal tissues nor in carcinomas. Normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus. Melanosome. Endosome, multivesicular body. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes predominantly to intralumenal vesicles (ILVs) within multivesicular bodies. Associates with ILVs found within the lumen of premelanosomes and melanosomes and particularly in compartments that serve as precursors to the striated stage II premelanosomes.; [M-alpha]: Secreted.
Diseases
- Melanoma
- Neoplasms
- Malignant Neoplasms
- Skin Neoplasms
- Neoplasm Metastasis
- Metastatic Melanoma
- Malignant Paraganglionic Neoplasm
- Melanoma, Experimental
- B16 Malignant Melanoma
- Autoimmune Reaction
- Melanocytic Nevus
- Autoimmunity
Pathways
- Immune Response
- Melanocyte Differentiation
- Pigmentation
- Secretion
- Sensitization
- Localization
- Transport
- Hypersensitivity
- Cell Proliferation
- Cytokine Secretion
- Reverse Transcription
- Cytokine Production
- Pathogenesis
PTMs
- Cleavage
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PMEL
bosterbio.com/bosterbio-gene-info-cards/PMEL
References
PMID: 1924386 by Kwon B.S., et al. A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12.
PMID: 8179825 by Maresh G.A., et al. Cloning and expression of the gene for the melanoma-associated ME20 antigen.