N-fatty-acyl-amino acid synthase/hydrolase PM20D1 (PM20D1)

Bidirectional N-fatty-acyl amino acid synthase/hydrolase that modulates the creation of N-fatty-acyl amino acids. These metabolites are endogenous chemical uncouplers of mitochondrial respiration.

In an UCP1-independent manner, maybe through interaction with mitochondrial transporters, they encourage proton leakage into the mitochondrial matrix. Thereby, this secreted protein may indirectly regulate the physiological dissipation of chemical energy as heat through thermogenic respiration.