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Cardiac phospholamban Antibodies
AND PLN ELISA kits, Cardiac phospholamban Proteins
Many biological assays use antibodies to detect Cardiac phospholamban, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cardiac phospholamban in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cardiac phospholamban antibodies...
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PLN Infographic by Boster Bio
All PLN Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IHC, WB
$370
Cat # A01395-1
100 μg/vial
Cat # A01395-1
100 μg/vial
Human, Mouse
WB
$370
Cat # M01395S16
100 µl/vial
Cat # M01395S16
100 µl/vial
PLN Overview
Facts about Cardiac phospholamban.
Cardiac phospholamban (PLN)
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2.
Modulates calcium re-uptake during muscle relaxation and plays an essential role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
Gene Information
| Human | |
|---|---|
| Gene Name: | PLN |
| Uniprot: | P26678 |
| Entrez: | 5350 |
Family
| Belongs to: |
|---|
| phospholamban family |
Alternative Names
CMD1PPLBcardiac phospholamban; phospholamban
Molecular Weight
Mass (kDA):
6.109 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q22.31 |
| Sequence: | 6; NC_000006.12 (118548296..118561716) |
Tissue Specificity
Heart muscle (at protein level).
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass membrane protein. Sarcoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Membrane; Single-pass membrane protein. Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648).
Diseases
- Malignant Neoplasms
- Heart Failure
- Neoplasm Metastasis
- Autoimmune Reaction
- Cardiomyopathies
- Lymphatic Metastasis
- Neoplasms
- Inflammation
- Endometriosis, Site Unspecified
- Diabetes Mellitus
- Graft Vs Host Reaction
- Carcinoma
- Tissue Adhesions
Interacting Proteins
- BCL2L13
- CREB3L1
- DMPK
- EDA
- LDLRAD1
Pathways
- Immune Response
- Pathogenesis
- Transport
- Hypersensitivity
- Lymphocyte Migration
- Localization
- Cell Proliferation
- Sensitization
- Cell Activation
- Secretion
- Lymphocyte Proliferation
- Virulence
- Inflammatory Response
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Glycosylation
- Reduction
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLN
bosterbio.com/bosterbio-gene-info-cards/PLN
References
PMID: 1828805 by Fujii J., et al. Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6.
PMID: 10198197 by McTiernan C.F., et al. The human phospholamban gene: structure and expression.