PLOD1 Antibodies

AND PLOD1 ELISA kits, PLOD1 Proteins

Many biological assays use antibodies to detect PLOD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLOD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLOD1 antibodies...

We validate the specificity of these antibodies to PLOD1 by testing them on tissues known to express PLOD1 positively and negatively. Browse below to find the PLOD1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PLOD1 Infographic by Boster Bio

All PLOD1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-PLOD1 Antibody

Human, Mouse, Rat

$405
Cat # A05322
100ul

Anti-PLOD1 Antibody (C-term)

Human

$299
Cat # M05322
50 µl

PLOD1 (NM_000302) Human Over-expression Lysate

Human

$628
Cat # LS005351
100 µg

Anti-PLOD1 Antibody Picoband®

Human

ELISA, WB

$370
Cat # A05322-1
100 µg/vial

PLOD1 Overview

Facts about Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1.

PLOD1 3D structure. Source: alphafold

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1)

Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is needed for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:8621606, PubMed:10686424, PubMed:15854030).

These hydroxylysines serve as sites of attachment for carbohydrate components and are vital for the stability of the intermolecular collagen cross-links (Probable). .

Gene Information

Human
Gene Name:	PLOD1
Uniprot:	Q02809
Entrez:	5351

Family

Belongs to:

No superfamily

Alternative Names

2-oxoglutarate 5-dioxygenase 1; EC 1.14.11.4; Ehlers-Danlos syndrome type VI); FLJ42041; LH1; LLH; lysine hydroxylase; Lysyl hydroxylase 1; PLODLH; procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase; procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1; procollagen-lysine; procollagen-lysine, 2-oxoglutarate 5-dioxygenase

Molecular Weight

Mass (kDA):
83.55 kDA

Genomic Context


Human

Location:	1p36.22
Sequence:	1; NC_000001.11 (11934717..11975537)

Subcellular Localizations

Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.

Diseases

Ehlers-danlos Syndrome
Connective Tissue Diseases
Muscle Hypotonia
Kyphoscoliosis Deformity Of Spine
Acquired Kyphosis
Joint Laxity
Osteoporosis
Osteopenia
Neoplasms
Scoliosis, Unspecified
Dysequilibrium Syndrome
Ehlers-danlos Syndrome, Hydroxylysine-deficient
Corneal Diseases

Cholangiocarcinoma
Aneurysm
Collagen Diseases
Neoplasm Metastasis
Hyperhomocysteinemia
Malignant Neoplasm Of Breast
Swine Diseases

Interacting Proteins

HNRNPH2

Pathways

Cell Cycle
Transport
Osteoblast Differentiation
Aging
Regulation Of Gene Expression
Histone Modification
Metaphase
Oocyte Maturation
Biosynthetic Process
Rna Splicing
Flight

Translation
Steroid Biosynthetic Process
Heart Development
Pathogenesis
Transdifferentiation
Chromatin Remodeling

PTMs

Hydroxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLOD1

References

PMID: 1577494 by Hautala T., et al. Cloning of human lysyl hydroxylase: complete cDNA-derived amino acid sequence and assignment of the gene (PLOD) to chromosome 1p36.3- p36.2.

PMID: 7713497 by Heikkinen J., et al. Structure and expression of the human lysyl hydroxylase gene (PLOD): introns 9 and 16 contain Alu sequences at the sites of recombination in Ehlers-Danlos syndrome type VI patients.