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PLK3 Antibodies
AND PLK3 ELISA kits, PLK3 Proteins
Many biological assays use antibodies to detect PLK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLK3 antibodies...
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PLK3 Overview
Facts about Serine/threonine-protein kinase PLK3.
Serine/threonine-protein kinase PLK3 (PLK3)
Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a particular motif recognized by the POLO box domains.
Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entrance into S phase and cytokinesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | PLK3 |
| Uniprot: | Q9H4B4 |
| Entrez: | 1263 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CNK; CNKpolo-like kinase 3 (Drosophila); cytokine-inducible kinase; Cytokine-inducible serine/threonine-protein kinase; EC 2.7.11; FNK; FNKEC 2.7.11.21; PLK3; polo-like kinase 3PLK-3; PRK; PRKFGF-inducible kinase; Proliferation-related kinase; serine/threonine-protein kinase PLK3
Molecular Weight
Mass (kDA):
71.629 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p34.1 |
| Sequence: | 1; NC_000001.11 (44799952..44805995) |
Tissue Specificity
Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor.
Subcellular Localizations
Cytoplasm. Nucleus. Nucleus, nucleolus. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Translocates to the nucleus upon cisplatin treatment. Localizes to the Golgi apparatus during interphase. According to a report, PLK3 localizes only in the nucleolus and not in the centrosome, or in any other location in the cytoplasm (PubMed:17264206). The discrepancies in results may be explained by the PLK3 antibody specificity, by cell line-specific expression or post-translational modifications.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Hypoxia
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Ischemia
- Tumor Angiogenesis
- Liver Carcinoma
- Infarction
- Tumor Progression
Interacting Proteins
- POU2F1
- PRNP
- VRK1
Pathways
- Cell Cycle
- Mitosis
- Cell Proliferation
- Cell Cycle Arrest
- Cytokinesis
- Localization
- Cell Death
- Cell Division
- Regulation Of Cell Cycle
- Interphase
- M Phase
- Dna Damage Checkpoint
- S Phase
PTMs
- Phosphorylation
- Methylation
- Dephosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLK3
bosterbio.com/bosterbio-gene-info-cards/PLK3
References
PMID: 11039900 by Holtrich U., et al. Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages.
PMID: 8702627 by Li B., et al. Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas.