Perilipin-5 (Plin5)

Lipid droplet-associated protein that keeps the equilibrium between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by controlling both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation.

In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three important key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduce the triacylglycerol hydrolase activity of PNPLA2 by recruitment and sequestering PNPLA2 to lipid droplets.