PLCZ1 Antibodies

AND PLCZ1 ELISA kits, PLCZ1 Proteins

Many biological assays use antibodies to detect PLCZ1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLCZ1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLCZ1 antibodies...

We validate the specificity of these antibodies to PLCZ1 by testing them on tissues known to express PLCZ1 positively and negatively. Browse below to find the PLCZ1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PLCZ1 Infographic by Boster Bio

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PLCZ1 Overview

Facts about 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1.

PLCZ1 3D structure. Source: alphafold

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (PLCZ1)

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner.

Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that's transferred from the sperm to the egg cytoplasm after gamete membrane fusion.

Gene Information

Human
Gene Name:	PLCZ1
Uniprot:	Q86YW0
Entrez:	89869

Family

Belongs to:

No superfamily

Alternative Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

Molecular Weight

Mass (kDA):
70.411 kDA

Genomic Context


Human

Location:	12p12.3
Sequence:	12; NC_000012.12 (18645529..18738052, complement)

Tissue Specificity

Expressed specifically in testis and sperm. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic-duct cells from patients with cystic fibrosis.

Subcellular Localizations

Nucleus. Cytoplasm, perinuclear region. Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity).

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLCZ1

References

PMID: 12416999 by Cox L.J., et al. Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes.

PMID: 14697805 by Zhu H., et al. Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C.