PLCG2 Antibodies

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2)

The creation of this second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It's an essential enzyme in transmembrane signaling.

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Gene Information

Human
Gene Name:	PLCG2
Uniprot:	P16885
Entrez:	5336

Family

Belongs to:
No superfamily

Alternative Names

EC 3.1.4.11; Phosphoinositide phospholipase C-gamma-2; phospholipase C gamma 2; phospholipase C, gamma 2 (phosphatidylinositol-specific); phospholipase C, gamma 2 (phosphatidylyinositol-specific); Phospholipase C-gamma-2,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; Phospholipase C-IV; PLCG2; PLCgamma 2; PLC-gamma 2; PLC-gamma-2; PLC-IV

Molecular Weight

Mass (kDA):
147.87 kDA

Genomic Context

Human
Location:	16q23.3
Sequence:	16; NC_000016.10 (81779291..81962685)

Diseases

• Immunologic Deficiency Syndromes
• Neoplasms
• Inflammation
• Inflammatory Disorder
• Autoimmunity
• Kidney Neoplasm
• Malignant Neoplasms
• Autoimmune Diseases
• Peritonitis
• Urticaria
• Tissue Adhesions
• Urticaria Due To Cold
• Autoimmune Reaction

• Thymoma
• Enterocolitis
• Infertility
• Malignant Tumor Of Cervix
• Carcinoma
• Renal Cell Carcinoma
• Cervical Adenocarcinoma

Interacting Proteins

• AR
• EGFR
• EPOR
• ERBB2
• GAB1

• KIT
• PIK3R1
• PSMD3
• SH2D1B

Pathways

• Integrin Activation
• Secretion
• Osteoclast Development
• Mitosis
• Brain Development
• Immune Response
• Platelet Activation
• Intracellular Signal Transduction
• Endocytosis
• Reverse Transcription
• Sensitization
• System Development

• Axon Guidance
• Cell Cycle
• Cell Death
• Nervous System Development
• Cognition
• Pathogenesis
• Rna Interference

PTMs

• Phosphorylation

Research Areas

• Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLCG2

Boster Bio - The Best Uses Of The PLCG2 Marker

There are likely to be many questions if you are considering purchasing a Boster Bio. We'll discuss the benefits of this gene marker as well as some troubleshooting suggestions. Find out more in this article. In addition to providing you with essential information regarding PLCG2 markers These guides can also assist you in determining the ideal optimization procedures for your experiments.

Boster Bio: Marker PLCG2

PLCG2 is a DNA fragment that contains the amino acid sequence CAG-G-CAG–G. It is used to diagnose a variety of illnesses, including cancer and inflammatory bowel disorder. Boster Bio offers highly-affinity primary antibodies against this DNA fragment, that have been validated for use in ELISA, Immunohistochemistry and Western Blotting.

Benefits

One of the markers with an ability to predict the future are those that are associated with the PLCG2 protein. This protein encodes a protein implicated in adaptive immunity and is related to autoimmunity. Studies have revealed that this gene could be involved in AD pathophysiology. Numerous studies have proven that PLCG2 is associated with a higher risk of LOAD. This marker has numerous benefits.