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PLCG1 Antibodies
AND PLCG1 ELISA kits, PLCG1 Proteins
Many biological assays use antibodies to detect PLCG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLCG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLCG1 antibodies...
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PLCG1 Infographic by Boster Bio
All PLCG1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, ICC, WB
$370
Cat # M00677
100 μl
Cat # M00677
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1473
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1473
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1993
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1993
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1994
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1994
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2108
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2108
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ICC, WB
$482
Cat # A00677Y1253
100ul
Cat # A00677Y1253
100ul
Human, Monkey, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00677Y783-1
100ul
Cat # A00677Y783-1
100ul
Human, Monkey, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00677Y771
100ul
Cat # A00677Y771
100ul
Human
$960
Cat # LS005335
100 µg
Cat # LS005335
100 µg
Human
WB
$370
Cat # M00677Y1253
100 µl/vial
Cat # M00677Y1253
100 µl/vial
PLCG1 Overview
Facts about 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)
Mediates the production of this second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Gene Information
| Human | |
|---|---|
| Gene Name: | PLCG1 |
| Uniprot: | P19174 |
| Entrez: | 5335 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
EC 3.1.4.11; gamma 1 (formerly subtype 148); monophosphatidylinositol phosphodiesterase; NCKAP3,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1; phospholipase C-148; Phospholipase C-gamma-1; Phospholipase C-II; PLC11-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; PLC148; PLC-148; PLCG1; PLCgamma 1; PLC-gamma 1; PLC-gamma-1; PLC-II1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; PPLCA; triphosphoinosi
Molecular Weight
Mass (kDA):
148.532 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q12 |
| Sequence: | 20; NC_000020.11 (41137519..41177626) |
Subcellular Localizations
Cell projection, lamellipodium. Cell projection, ruffle. Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
Diseases
- Malignant Neoplasms
- Bipolar Disorder
- Tissue Adhesions
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
- Neoplasms
- Mammary Neoplasms
- Cell Invasion
- Sclerosis
- Dyslipidemias
- Personality Disorders
- Infectious Mononucleosis
- Thymoma
Interacting Proteins
- ABL2
- AKT1
- AR
- ASAP1
- ASAP2
- CAV1
- CD22
- CD244
- DUSP15
- EGFR
Pathways
- Pathogenesis
- Cell Adhesion
- Cell Activation
- T Cell Activation
- Localization
- Secretion
- Cell Migration
- Programmed Cell Death
- Aging
- Cell Cycle
- Cell Death
- Transport
- Osteoclast Differentiation
PTMs
- Phosphorylation
Research Areas
- Lipid and Metabolism
- Phospho-Specific
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLCG1
bosterbio.com/bosterbio-gene-info-cards/PLCG1
References
PMID: 2167438 by Burgess W.H., et al. Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
PMID: 1656221 by Mohammadi M., et al. A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.