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, No Gclids
Plcd4 Antibodies
AND Plcd4 ELISA kits, Plcd4 Proteins
Many biological assays use antibodies to detect Plcd4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Plcd4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Plcd4 antibodies...
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Plcd4 Infographic by Boster Bio
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Plcd4 Overview
Facts about 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (Plcd4)
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to create 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), whilst IP3 releases Ca(2+) from intracellular stores.
Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization from the zona pellucida- induced acrosome reaction. May play a role in cell growth.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Plcd4 |
| Uniprot: | Q8K3R3 |
| Entrez: | 18802 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
EC 3.1.4.11; hPLCD4; MGC12837; Phosphoinositide phospholipase C-delta-4; phospholipase C, delta 4; Phospholipase C-delta-4; PLC delta4; PLC-delta-4,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4
Molecular Weight
Mass (kDA):
92.694 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 1 C3|1 38.54 cM |
| Sequence: | 1; |
Diseases
- Malignant Neoplasms
- Neoplasms
- Liver Regeneration Disorder
- Diabetes Mellitus, Non-insulin-dependent
- Cell Transformation, Neoplastic
- Liver Carcinoma
- Insulinoma
- Malignant Neoplasm Of Breast
Pathways
- Acrosome Reaction
- Fertilization
- Cell Proliferation
- Insulin Secretion
- Localization
- Insemination
- Spermatogenesis
- Regeneration
- Cell Cycle
- S Phase
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Plcd4
bosterbio.com/bosterbio-gene-info-cards/Plcd4
References
PMID: 10601847 by Fukami K., et al. Growth factor-induced promoter activation of murine phospholipase C delta4 gene.
PMID: 11340203 by Fukami K., et al. Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction.