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- Table of Contents
Facts about 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1.
Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Human | |
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Gene Name: | PLCG1 |
Uniprot: | P19174 |
Entrez: | 5335 |
Belongs to: |
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No superfamily |
EC 3.1.4.11; gamma 1 (formerly subtype 148); monophosphatidylinositol phosphodiesterase; NCKAP3,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1; phospholipase C-148; Phospholipase C-gamma-1; Phospholipase C-II; PLC11-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; PLC148; PLC-148; PLCG1; PLCgamma 1; PLC-gamma 1; PLC-gamma-1; PLC-II1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; PPLCA; triphosphoinosi
Mass (kDA):
148.532 kDA
Human | |
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Location: | 20q12 |
Sequence: | 20; NC_000020.11 (41137519..41177626) |
Cell projection, lamellipodium. Cell projection, ruffle. Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
PMID: 2167438 by Burgess W.H., et al. Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
PMID: 1656221 by Mohammadi M., et al. A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.