UBR5 Antibodies

AND UBR5 ELISA kits, UBR5 Proteins

Many biological assays use antibodies to detect UBR5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBR5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBR5 antibodies...

We validate the specificity of these antibodies to UBR5 by testing them on tissues known to express UBR5 positively and negatively. Browse below to find the UBR5 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UBR5 Infographic by Boster Bio

All UBR5 Products

Product

Figures

Specificity

Applications

Price

EDD Colorimetric Cell-Based ELISA Kit

Human, Mouse

ELISA

$480
Cat # EKC1179
1 kit, containing one 96-well plate and all necessary reagents

Anti-HYD (T14) UBR5 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A03160T14
100ul

Anti-UBR5 Antibody

Human, Mouse

ELISA, IHC, WB

$380
Cat # A03160
100ul

Anti-EDD Rabbit Monoclonal Antibody

Human, Mouse

$370
Cat # M03160
100 μl/vial

UBR5 Overview

Facts about E3 ubiquitin-protein ligase UBR5.

E3 ubiquitin-protein ligase UBR5 (UBR5)

E3 ubiquitin-protein ligase which is a part of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, resulting in their ubiquitination and subsequent degradation (By similarity).

Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression.

Gene Information

Human
Gene Name:	UBR5
Uniprot:	O95071
Entrez:	51366

Family

Belongs to:

No superfamily

Alternative Names

DD5; E3 ubiquitin protein ligase, HECT domain containing, 1; E3 ubiquitin-protein ligase, HECT domain-containing 1; EC 6.3.2; EC 6.3.2.-; EDD; EDD1; EDD1E3 ubiquitin-protein ligase UBR5; EDDE3 identified by differential display; hHYD; HYD; HYDFLJ11310; Hyperplastic discs protein homolog; KIAA0896MGC57263; progestin induced protein; Progestin-induced protein; ubiquitin protein ligase E3 component n-recognin 5; ubiquitin-protein ligase; UBR5

Molecular Weight

Mass (kDA):
309.352 kDA

Genomic Context


Human

Location:	8q22.3
Sequence:	8; NC_000008.11 (102252273..102412700, complement)

Tissue Specificity

Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Hyperplasia
Cell Transformation, Neoplastic
Malignant Neoplasm Of Breast
Carcinoma
Mammary Neoplasms
Malignant Neoplasm Of Ovary
Ovarian Neoplasm
Liver Carcinoma
Allelic Imbalance
Stomach Neoplasms
Malignant Neoplasm Of Tongue

Melanoma
Anosmia
Ataxia
Dementia
Immunologic Deficiency Syndromes
Epithelial Ovarian Cancer
Mild Cognitive Disorder

Interacting Proteins

CTNNB1
GSK3B
PAIP2

Pathways

Proteolysis
Translation
Cell Cycle
Cell Proliferation
Dna Damage Checkpoint
Rna Interference
Gluconeogenesis
Cell Death
Ras Protein Signal Transduction
Transport
Cell Cycle Arrest
Carbon Dioxide Transport
Water Transport

Cognition
Catabolic Process
Oncogenesis
Gastrulation
Mitochondrion Transport Along Microtubule
Mitosis
Dna Methylation

PTMs

Ubiquitination
Phosphorylation

Acetylation
Reduction

Deacetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBR5

References

PMID: 10030672 by Callaghan M.J., et al. Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs.

PMID: 11714696 by Honda Y., et al. Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.