PKD2L1 Antibodies

AND PKD2L1 ELISA kits, PKD2L1 Proteins

Many biological assays use antibodies to detect PKD2L1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PKD2L1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PKD2L1 antibodies...

We validate the specificity of these antibodies to PKD2L1 by testing them on tissues known to express PKD2L1 positively and negatively. Browse below to find the PKD2L1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PKD2L1 Infographic by Boster Bio

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PKD2L1 (NM_016112) Human Over-expression Lysate

Human

$628
Cat # LS009033
100 µg

PKD2L1 Overview

Facts about Polycystic kidney disease 2-like 1 protein.

PKD2L1 3D structure. Source: alphafold

Polycystic kidney disease 2-like 1 protein (PKD2L1)

Pore-forming subunit of a heterotetrameric, non- selective cation channel that is permeable to Ca(2+) (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:23212381, PubMed:30004384). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but doesn't affect cytoplasmic calcium concentration (PubMed:24336289).

The channel formed by PKD1L2 and PKD1L1 in primary cilia governs sonic hedgehog/SHH indicating and GLI2 transcription (PubMed:24336289). Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour flavor perception in gustatory cells (PubMed:19812697).

Gene Information

Human
Gene Name:	PKD2L1
Uniprot:	Q9P0L9
Entrez:	9033

Family

Belongs to:

polycystin family

Alternative Names

Polycystic kidney disease 2-like 1 protein

Molecular Weight

Mass (kDA):
91.982 kDA

Genomic Context


Human

Location:	10q24.31
Sequence:	10; NC_000010.11 (100288145..100347030, complement)

Tissue Specificity

Detected in taste bud cells in fungiform papillae (at protein level) (PubMed:19812697). Ubiquitous (PubMed:9748274). Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver (PubMed:9748274, PubMed:9878261). Isoform 4 appears to be expressed only in transformed lymphoblasts.

Subcellular Localizations

Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane.

PTMs

Disulfide bond
Glycoprotein

Lipoprotein
Palmitate

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PKD2L1

References

PMID: 9748274 by Nomura H., et al. Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects.

PMID: 10602992 by Guo L., et al. The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism.