CCRL2 Antibodies

AND CCRL2 ELISA kits, CCRL2 Proteins

Many biological assays use antibodies to detect CCRL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CCRL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CCRL2 antibodies...

We validate the specificity of these antibodies to CCRL2 by testing them on tissues known to express CCRL2 positively and negatively. Browse below to find the CCRL2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CCRL2 Infographic by Boster Bio

All CCRL2 Products

Product

Figures

Specificity

Applications

Price

Anti-CCRL2/Cram A Antibody

5 Q&As

Human

ELISA, IF, ICC, WB

$399
Cat # A09152
100μl

CCRL2 Overview

Facts about C-C chemokine receptor-like 2.

CCRL2 3D structure. Source: alphafold

C-C chemokine receptor-like 2 (CCRL2)

Receptor for CCL19 and chemerin/RARRES2.
Does not seem to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by catching and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors.

Plays a crucial role for the development of Th2 responses. .

Gene Information

Human
Gene Name:	CCRL2
Uniprot:	O00421
Entrez:	9034

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

CCRL2/LCCR; LCCR

Molecular Weight

Mass (kDA):
39.513 kDA

Genomic Context


Human

Location:	3p21.31
Sequence:	3; NC_000003.12 (46407166..46409523)

Tissue Specificity

Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T- cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Inflammation
Cholangiocarcinoma
Malignant Neoplasms
Dysequilibrium Syndrome
Acquired Immunodeficiency Syndrome
Immunologic Deficiency Syndromes
Neoplasms
Rheumatoid Arthritis
Hepatitis
Arthritis
Cardiovascular Diseases
Pertussis
Pneumonia

Hiv Infections
Autoimmunity
Sclerosis
Hepatitis C, Chronic
Glioma
Hepatitis B
Low Grade Lymphoma (neoplasm)

Pathways

Immune Response
Cell Migration
Chemotaxis
Pathogenesis
Secretion
Anaphylaxis
Localization
Leukocyte Migration
Glucose Homeostasis
Coagulation

Bone Remodeling
Angiogenesis
Rna Interference
Bone Resorption

PTMs

Phosphorylation

Biotinylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCRL2

References

PMID: 9473515 by Fan P., et al. Cloning and characterization of a novel human chemokine receptor.

PMID: 11828366 by Migeotte I., et al. Distribution and regulation of expression of the putative human chemokine receptor HCR in leukocyte populations.