PJA2 Antibodies

E3 ubiquitin-protein ligase Praja-2 (PJA2)

Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation.

Essential for PKA- mediated long-term memory systems. .

Gene Information

Human
Gene Name:	PJA2
Uniprot:	O43164
Entrez:	9867

Family

Belongs to:
No superfamily

Alternative Names

E3 ubiquitin-protein ligase Praja-2; EC 6.3.2; EC 6.3.2.-; KIAA0438praja2; Neurodap1; praja ring finger 2; Praja2; RING finger protein 131praja 2, RING-H2 motif containing; RNF131

Molecular Weight

Mass (kDA):
78.214 kDA

Genomic Context

Human
Location:	5q21.3
Sequence:	5; NC_000005.10 (109334709..109409978, complement)

Subcellular Localizations

Cytoplasm. Cell membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses (By similarity). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane.

Diseases

• Disease Of Adrenal Medulla

Pathways

• Protein Ubiquitination

PTMs

• Ubiquitination

Research Areas

• Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PJA2

Boster Bio - Best Uses Of The PJA2 Marker

Boster Bio is an innovative biotechnology company that specializes exclusively in high-affinity primary antibody production. We will learn more about Boster Bio and his products in this article. We will also learn about his company's history and the products he offers. This information will allow you to make informed decisions about PJA2 Marker. The PJA2 mark is a protein that can be found on many human tissues.

Boster provides high-affinity primary antibodies

If you're looking for high-affinity primary antibodies, you've come to the right place. Boster Bio has a wide range of antibodies that have been highly cited and are trusted by researchers. These antibodies are validated for use in ELISA, Western Blotting, and Immunohistochemistry. More information is available about these antibodies. Boster antibodies are ideal for those who work with target proteins or need an antigen-detection antibody.

Single B cell screening is a quick and efficient method to isolate high-affinity primaries antibodies for a given antigen in just a few days. This involves the isolation of viable cells from patients in convalescence or animals that have been immunized with target antigen. Next, these cells can be sorted using single cell sorting and expression. Researchers can now begin to evaluate potential therapeutic uses for the antibodies once they are isolated.

High-affinity primary antibody are useful for research in many areas, including molecular diagnosing. Antibodies can not only determine the presence or absence a target protein but also assist in the identification of specific proteins and other biological compounds. Primary antibodies are the key ingredient in immunoassays. They rely on the ability to bind antigens and detect a specific protein or genetic material. Examples of immunoassays include Western Blotting, immunohistochemistry, and histopathology tests. Flow Cytometry is a useful tool for measuring the number of specific cell types.

These antibodies have been tested, and they have been shown to be highly effective at binding to the SARS/CoV-2 receptor-binding region. These antibodies also have a low level of neutralizing activity, despite their high affinity. VHH72 and VI1 have high affinity to SARSCoV-2. For comparison, the positive control antibody, CB6, was used. The average of three independent experiments is used to calculate the results.