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- Table of Contents
Facts about Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha.
The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis.
Human | |
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Gene Name: | PIP5K1A |
Uniprot: | Q99755 |
Entrez: | 8394 |
Belongs to: |
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No superfamily |
68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha; EC 2.7.1; EC 2.7.1.68; Phosphatidylinositol-4-phosphate 5-kinase type I alpha; phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; PIP5K1-alpha; PIP5KIalpha; PtdIns(4)P-5-kinase 1 alpha
Mass (kDA):
62.633 kDA
Human | |
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Location: | 1q21.3 |
Sequence: | 1; NC_000001.11 (151197954..151249536) |
Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver.
Cell membrane. Cytoplasm. Nucleus speckle. Cell projection, ruffle. Cell projection, lamellipodium. Nucleus. Colocalizes with RAC1 at actin-rich membrane ruffles. Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs.
PMID: 8955136 by Loijens J.C., et al. Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family.
PMID: 15157668 by Luo B., et al. Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism.