This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
PINK1 Antibodies
AND PINK1 ELISA kits, PINK1 Proteins
Many biological assays use antibodies to detect PINK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PINK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PINK1 antibodies...
Previous: Septin9
Next: Kcnip1
PINK1 Infographic by Boster Bio
All PINK1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00201-2
100 μg/vial
Cat # A00201-2
100 μg/vial
PINK1 Overview
Facts about Serine/threonine-protein kinase PINK1, mitochondrial.
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291).
Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in two steps: (1) by mediating phosphorylation in'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291).
Gene Information
| Human | |
|---|---|
| Gene Name: | PINK1 |
| Uniprot: | Q9BXM7 |
| Entrez: | 65018 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
PINK1; BRPK; BRPK; EC 2.7.11.1; FLJ27236; Mitochondrial; PARK6; Parkinson disease (autosomal recessive) 6; PINK1; PINK1 mouse; PINK1 polyclonal; PINK1; protein kinase BRPK; PTEN Induced Kinase 1; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; serine/threonine-protein kinase PINK1, mitochondrial
Molecular Weight
Mass (kDA):
62.769 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.12 |
| Sequence: | 1; NC_000001.11 (20633458..20651511) |
Tissue Specificity
Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
Subcellular Localizations
Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion inner membrane; Single-pass membrane protein. Cytoplasm, cytosol. Localizes mostly in mitochondrion and the 2 proteolytic processed fragments of 55 kDa and 48 kDa localize mainly in cytosol.
Diseases
- Parkinson Disease
- Secondary Parkinson Disease
- Neurodegenerative Disorders
- Nerve Degeneration
- Movement Disorders
- Parkinsonism, Autosomal Recessive
- Mitochondrial Diseases
- Alzheimer's Disease
- Malnutrition
- Dementia
- Mitochondrial Damage
- Abnormal Degeneration
Interacting Proteins
- FBXO7
- MAP1LC3B
- PRKN
- RHOT1
- SOCS4
- TRAP1
Pathways
- Pathogenesis
- Autophagy
- Cell Death
- Localization
- Aging
- Transport
- Mitochondrial Fission
- Electron Transport
- Mitochondrial Fusion
- Translation
- Macroautophagy
- Electron Transport Chain
- Oxidative Phosphorylation
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Alzheimers Research
- Autophagy
- DNA Repair
- Lipid and Metabolism
- Mitochondrial Markers
- Mitophagy
- Neurodegeneration
- Neuronal Cell Markers
- Neuroscience
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PINK1
bosterbio.com/bosterbio-gene-info-cards/PINK1
References
PMID: 11494141 by Unoki M., et al. Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.
PMID: 14607334 by Nakajima A., et al. BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential.