PILRA Antibodies

AND PILRA ELISA kits, PILRA Proteins

Many biological assays use antibodies to detect PILRA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PILRA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PILRA antibodies...

We validate the specificity of these antibodies to PILRA by testing them on tissues known to express PILRA positively and negatively. Browse below to find the PILRA antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PILRA Infographic by Boster Bio

All PILRA Products

Product

Figures

Specificity

Applications

Price

PILRA (NM_013439) Human Over-expression Lysate

Human

$628
Cat # LS029992
100 µg

Anti-PILRA Antibody Picoband™

Human

ELISA, Flow Cytometry, WB

$370
Cat # A07502-1
100 µg/vial

Human PILRA ELISA Kit PicoKine®

Human

ELISA

$499
Cat # EK2255
96 wells/kit, with removable strips.

PILRA Overview

Facts about Paired immunoglobulin-like type 2 receptor alpha.

PILRA 3D structure. Source: alphafold

Paired immunoglobulin-like type 2 receptor alpha (PILRA)

Paired receptors consist of highly related activating and inhibitory receptors and are commonly involved in the regulation of the immune system. PILRA is thought to serve as a mobile signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 through their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Receptor for PIANP. .

Gene Information

Human
Gene Name:	PILRA
Uniprot:	Q9UKJ1
Entrez:	29992

Family

Belongs to:

No superfamily

Alternative Names

Cell surface receptor FDF03; FDF03; inhibitory receptor PILRalpha; Inhibitory receptor PILR-alpha; paired immunoglobin-like receptor alpha; paired immunoglobin-like type 2 receptor alpha; paired immunoglobulin-like receptor alpha; paired immunoglobulin-like type 2 receptor alpha; PILRA; PILRalpha; PILR-alpha

Molecular Weight

Mass (kDA):
34.005 kDA

Genomic Context


Human

Location:	7q22.1
Sequence:	7; NC_000007.14 (100372659..100400098)

Tissue Specificity

Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors.

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.

Diseases

Infective Disorder
Cell Invasion
Pseudorabies
Retinal Necrosis Syndrome, Acute
Tissue Adhesions
Retinal Detachment
Melanoma, Experimental
Arthritis
Rhegmatogenous Retinal Detachment

Systemic Onset Juvenile Chronic Arthritis
Dental Plaque
Inflammation
Arthritis, Juvenile Rheumatoid

Interacting Proteins

PTPN6

Pathways

Membrane Fusion
Cell Activation
Cell Proliferation
Cell-cell Recognition
T Cell Activation
Immune Response
Endocytosis
Tropism
Virulence
Localization
Gene Conversion
T Cell Proliferation

Integrin Activation
Regulation Of Immune Response
Monocyte Differentiation
Pathogenesis
Viral Replication
Secretion

PTMs

Phosphorylation
Glycosylation

Reduction
Dephosphorylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PILRA

References

PMID: 10660620 by Mousseau D.D., et al. PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif- bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta.

PMID: 10903717 by Fournier N., et al. FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells.