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Pikfyve Antibodies
AND Pikfyve ELISA kits, Pikfyve Proteins
Many biological assays use antibodies to detect Pikfyve, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pikfyve in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pikfyve antibodies...
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Pikfyve Infographic by Boster Bio
All Pikfyve Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC-P, ICC
$335
Cat # P02638
100ul
Cat # P02638
100ul
Human, Mouse
ELISA
$480
Cat # EKC1461
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1461
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC
$380
Cat # A02638S307
100ul
Cat # A02638S307
100ul
Human, Mouse, Rat
IHC, WB
$523
Cat # M02638
100 µl
Cat # M02638
100 µl
Pikfyve Overview
Facts about 1-phosphatidylinositol 3-phosphate 5-kinase.
1-phosphatidylinositol 3-phosphate 5-kinase (Pikfyve)
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate.
Required for endocytic-vacuolar pathway and nuclear migration. The product of this reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Pikfyve |
| Uniprot: | Q9Z1T6 |
| Entrez: | 18711 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
1-phosphatidylinositol-3-phosphate 5-kinase; EC 2.7.1.150; FAB1; FLJ37746; FYVE finger-containing phosphoinositide kinase; KIAA0981CFD; MGC40423; p235; Phosphatidylinositol-3-phosphate 5-kinase type III; Phosphatidylinositol-3-phosphate 5-kinase; phosphoinositide kinase, FYVE finger containing; PIKFyve; PIP5K; PIP5K3; PIP5K3FAB1; PIPkin-III; Type III PIP kinase; type III
Molecular Weight
Mass (kDA):
236.877 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 1|1 C2 |
| Sequence: | 1; |
Tissue Specificity
Ubiquitous.
Diseases
- Dystrophy
- Charcot-marie-tooth Disease
- Neurodegenerative Disorders
- Nerve Degeneration
- Sclerosis
- Primary Lateral Sclerosis
- Amyotrophic Lateral Sclerosis
- Malignant Neoplasms
- Corneal Diseases
- Neoplasms
- Lymphoma
Pathways
- Transport
- Localization
- Endocytosis
- Autophagy
- Exocytosis
- Glucose Transport
- Endosomal Transport
- Secretion
- Glucose Homeostasis
- Membrane Fission
- Oncogenesis
- Cell Death
- Vacuolar Acidification
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pikfyve
bosterbio.com/bosterbio-gene-info-cards/Pikfyve
References
PMID: 9858586 by Shisheva A., et al. Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells.
PMID: 10567352 by McEwen R.K., et al. Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases.