PIK3CG Antibodies

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins into the membrane, including AKT1 and PDPK1, triggering signaling cascades involved in cell growth, survival, proliferation, motility and morphology.

Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic reactions.

Gene Information

Human
Gene Name:	PIK3CG
Uniprot:	P48736
Entrez:	5294

Family

Belongs to:
PI3/PI4-kinase family

Alternative Names

1-phosphatidylinositol 3-kinase; EC 2.7.1; EC 2.7.1.153; p110-gamma; p120-PI3K; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gamma; phosphatidylinositol 3-kinase, catalytic, gamma polypeptide; Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphoinositide-3-kinase gamma catalytic subunit; phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI 3Kinase p110 gamma; PI 3-Kinase p110 gamma; PI3CG; PI3K; PI3K-gamma ; PI3Kgamma; PI3K

Molecular Weight

Mass (kDA):
126.454 kDA

Genomic Context

Human
Location:	7q22.3
Sequence:	7; NC_000007.14 (106865282..106908980)

Tissue Specificity

Pancreas, skeletal muscle, liver and heart.

Subcellular Localizations

Cytoplasm. Cell membrane.

Diseases

• Inflammation
• Tissue Adhesions
• Malignant Neoplasms
• Neoplasms
• Autoimmune Reaction
• Heart Failure
• Arthritis
• Asthma
• Edema
• Rheumatoid Arthritis
• Cell Transformation, Neoplastic
• Pneumonia
• Infarction

• Fibrosis
• Autoimmune Diseases
• Pertussis
• Heart Diseases
• Myocardial Infarction
• Bronchial Hyperreactivity
• Ischemia

Interacting Proteins

• PDE3B
• Pik3r6

Pathways

• Chemotaxis
• Cell Migration
• Secretion
• Cell Proliferation
• Localization
• Cell Motility
• Pathogenesis
• Angiogenesis
• Cell Activation
• Neutrophil Chemotaxis
• Inflammatory Response
• Cell Growth
• Platelet Aggregation

• Insulin Secretion
• Cytokine Production
• Cell Adhesion
• T Cell Activation
• Leukocyte Chemotaxis
• Integrin Activation
• Leukocyte Migration

PTMs

• Phosphorylation
• Dephosphorylation
• Demethylation

• Reduction
• Cleavage
• Methylation

Research Areas

• mTOR Pathway
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIK3CG

Boster Bio - Best Uses Of The PIK3CG Marker

This article will examine Boster Bio and the PIK3CG marker. Additionally it will discuss IGF2 and the PI3K gamma. PIK3CG is an indicator for the kinase PIK3C which is a key factor in the creation of IGF2. This article will help you make informed decisions regarding whether you're looking for a PIK3CG anti-body or an IGF2 inhibitor.

Boster Bio

The PIK3CG gene encodes an enzyme which phosphorylates the phosphoinositides. Numerous single nucleotide variants in this gene have clinical significance. The most notable is rs342286 located 140 kb to the right of the PIK3CG gene. In the past, SNPs located near PIK3CG have been associated with an increase in platelet aggregation. Recently, Wain et al. A new locus (30) was identified close to PIK3CG.

PI3K-gamma

The PIK3CG gene is an important target for therapeutic drugs. Boster Bio offers highly specific and high-affinity anti-mAbs that target this PIK3CG target. This mAb is extensively cited by the scientific community and has been tested using ELISA, Western Blotting, and Immunohistochemistry techniques. It is highly specific and highly sensitive, which allows researchers to carry out a variety of applications.

The PI3K-a kinase is a kinas ATP phosphate in a similar way to the PI3K g marker. However, the PI3K-a kinase also has two docking locations one at the nucleotide end and the one located at the protein's C -terminus. To form hydrogen bonds with Val 851 near the nucleotide's end Both docking sites require three hydroxyl groups.

Del blocks Akt and PI3K activity in NHEK cell. It blocks Akt/PI3K/Akt/mTOR activity and reduces the production of proinflammatory cytokines. It is a p–gpik inhibitor that has a wide range of applications. The best uses of the marker PIK3CG

IGFs are well-known to regulate PI3K/Akt signaling by activating IGF1R. IGF2 is an inhibitor of PI3K-Akt activity in these cells, and PIK3CG is among the most well-known targets of this signaling pathway. The PI3K-Akt pathway is the main regulator of cell proliferative capacity. It is crucial to keep in mind that IGF2 overexpression can negatively impact PI3K3CG transcription.

PIK3CG

The catalytic subunit of the PI3K protein is encoded by the PIK3CG gene. PIK3CG is extremely expressed in the aortas of human lesions and in mouse models of AS. Studies have also proven that a PIK3CG-specific inhibitor slowed the development AS in LDLR mice. PIK3CG is a key regulator of HDL clearance.

The PIK3CG marker has a myriad of applications. It can be used to detect and analyze PIK3G-deficient mice that reproduce the symptoms of human diseases. The gene is crucial for encouraging adaptive immune responses as well as reducing inflammation. Although these findings are encouraging, future studies need to confirm their use in human clinical trials. There is the PIK3CG gene in a variety of tissues. The best method for analyzing it is to examine the expression patterns in human tissues.

One study that was conducted on mice revealed several mutations in the PIK3CG gene. This study revealed that the gene was controlled by miR146b-3p. Mice treated with miR146b-3p mimics showed a decrease in gene expression. Immunopathology was observed in mice model that were PIK3CG-deficient. It also showed decreased expression of other immune genes.

As a potential therapeutic target for atherosclerosis, the PIK3CG gene was identified. In mice that lack PIK3CG, the expression of macrophage markers M2 was decreased. In addition, mice with impaired PIK3CG expression showed increased insulin resistance and decreased inflammation. These findings suggest that the PI3Kg gene could be a therapeutic target for diabetes.