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PIAS1 Antibodies
AND PIAS1 ELISA kits, PIAS1 Proteins
Many biological assays use antibodies to detect PIAS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIAS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIAS1 antibodies...
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PIAS1 Infographic by Boster Bio
All PIAS1 Products
Product
Figures
Specificity
Applications
Price
Anti-E3 SUMO-protein ligase PIAS1 PIAS1 Antibody Picoband®
1 Citations 1 Q&As
Human, Mouse, Rat
IHC, ICC, WB
$370
Cat # PA2252
100 μg/vial
Cat # PA2252
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01707
100 μl
Cat # M01707
100 μl
Human, Mouse
ELISA
$480
Cat # EKC1457
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1457
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01707
100 μg/vial
Cat # A01707
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01707-1
100 μl/vial
Cat # M01707-1
100 μl/vial
PIAS1 Overview
Facts about E3 SUMO-protein ligase PIAS1.
E3 SUMO-protein ligase PIAS1 (PIAS1)
Functions as an E3-type little ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.
The effects of the transcriptional coregulation, transactivation or silencing, may change depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late period of interferon gamma (IFN-gamma) signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | PIAS1 |
| Uniprot: | O75925 |
| Entrez: | 8554 |
Family
| Belongs to: |
|---|
| PIAS family |
Alternative Names
AR interacting protein; DDXBP1MGC141878; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO-protein ligase PIAS1; GBPRNA helicase II-binding protein; GU/RH-II; Gu-binding protein; MGC141879; Protein inhibitor of activated STAT protein 1; protein inhibitor of activated STAT, 1; protein inhibitor of activated STAT-1; zinc finger, MIZ-type containing 3; ZMIZ3
Molecular Weight
Mass (kDA):
71.836 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q23 |
| Sequence: | 15; NC_000015.10 (68054315..68193847) |
Tissue Specificity
Expressed in numerous tissues with highest level in testis.
Subcellular Localizations
Nucleus speckle. Nucleus, PML body. Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.
Diseases
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Malignant Neoplasm Of Prostate
- Carcinoma
- Hepatitis
- Prostatic Neoplasms
- Cell Transformation, Neoplastic
- Hepatitis, Chronic
- Hepatitis C, Chronic
- Fibrosis
- Hepatitis C
- Leukemia
Interacting Proteins
- CASP8AP2
- MBD1
- PRDM1
- TP53
Pathways
- Localization
- Conjugation
- Methylation
- Cell Proliferation
- Cell Cycle
- Protein Sumoylation
- Cell Differentiation
- Inflammatory Response
- Spermatogenesis
- Receptor Transactivation
- Dna Methylation
- Dna Repair
- Cellular Localization
PTMs
- Sumoylation
- Phosphorylation
- Methylation
- Ubiquitination
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIAS1
bosterbio.com/bosterbio-gene-info-cards/PIAS1
References
PMID: 9724754 by Liu B., et al. Inhibition of Stat1-mediated gene activation by PIAS1.
PMID: 10628744 by Tan J., et al. Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis.
1 Publications of Boster PIAS1 Antibodies & ELISA Kits
- PubMed ID: 29212953, Scortegagna M1, Berthon A2, Settas N2, Giannakou A2, Garcia G1, Li JL1, James B1...
*More publications can be found for each product on its corresponding product page