Elafin Antibodies

Elafin (PI3)

Neutrophil and pancreatic elastase-specific inhibitor of skin. It might prevent elastase-mediated tissue proteolysis.

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Gene Information

Human
Gene Name:	PI3
Uniprot:	P19957
Entrez:	5266

Family

Belongs to:
No superfamily

Alternative Names

cementoin; Elafin; Elastase-specific inhibitor; ESI; ESIWAP four-disulfide core domain protein 14; Peptidase inhibitor 3; peptidase inhibitor 3, skin-derived; PI3; PI-3; pre-elafin; protease inhibitor 3, skin-derived (SKALP); Protease inhibitor WAP3; SKALP; SKALPELAFIN; Skin-derived antileukoproteinase; Trappin2; Trappin-2; WAP four-disulfide core domain 14; WAP3MGC13613; WFDC14elafin

Molecular Weight

Mass (kDA):
12.27 kDA

Genomic Context

Human
Location:	20q13.12
Sequence:	20; NC_000020.11 (45174902..45176544)

Subcellular Localizations

Secreted.

Diseases

• Malignant Neoplasms
• Neoplasms
• Inflammation
• Carcinoma
• Tissue Adhesions
• Tumor Angiogenesis
• Cell Transformation, Neoplastic
• Mammary Neoplasms
• Malignant Neoplasm Of Breast
• Diabetes Mellitus
• Malignant Paraganglionic Neoplasm
• Cell Invasion

• Ischemia
• Leukemia
• Neoplasm Metastasis
• Hypoxia
• Insulin Resistance
• Nervousness
• Virus Diseases

Pathways

• Cell Proliferation
• Cell Death
• Secretion
• Cell Cycle
• Cell Growth
• Angiogenesis
• Pathogenesis
• Cell Migration
• Localization
• Transport
• Immune Response
• Translation
• Autophagy

• Cell Cycle Arrest
• Chemotaxis
• Neuroprotection
• Inflammatory Response
• Cell Activation
• Cell Adhesion
• Rna Interference

PTMs

• Phosphorylation
• Cleavage
• Dephosphorylation
• Ubiquitination
• Oxidation
• Reduction
• Methylation
• Myristoylation
• Prenylation
• Ribosylation

• Deacetylation
• Glycosylation
• Biotinylation
• Carboxylation
• Farnesylation
• Acetylation
• Palmitoylation
• Sumoylation
• Nitration
• Geranylgeranylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PI3

Boster Bio - Best Uses Of The PI3 Marker

There are several ways to optimize your experiments, and using a Boster Bio optimization guide can help you do just that. These guides can provide a wealth of information and suggestions to help you optimize your experiments and get better results. Every researcher experiences problems during their experiments. Fortunately, proper controls can eliminate many of the possible sources of error. Troubleshooting guides are a great way to identify and eliminate potential troubleshooting problems and ensure a successful experiment.

Boster Bio: Best Use

The PI3 marker is a highly sensitive marker for cell death, a hallmark of cancer. It is part of a family of cysteine proteases that respond to a variety of apoptotic stimuli, including cell surface or mitochondrial stimuli. Some pro-apoptotic stimuli include tumor necrosis factor (TNF), growth factor receptor-bound proteins, granzyme-B DNA damage, calcium channels, and others. In addition to PI3, Boster Bio offers ELISA kits that detect hormones, small molecules, and oxidative stress.