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- Table of Contents
Facts about Pleckstrin homology-like domain family A member 1.
May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic ramifications of IGF1.
Mouse | |
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Gene Name: | Phlda1 |
Uniprot: | Q62392 |
Entrez: | 21664 |
Belongs to: |
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No superfamily |
Apoptosis-associated nuclear protein; DT1P1B11; MGC131738; PHRIPT-cell death-associated gene 51 protein; pleckstrin homology-like domain family A member 1; pleckstrin homology-like domain, family A, member 1; PQ-rich protein; Proline- and glutamine-rich protein; Proline- and histidine-rich protein; proline-histidine rich protein; TDAG51PQR protein
Mass (kDA):
45.583 kDA
Mouse | |
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Location: | 10|10 D1 |
Sequence: | 10; |
Widely expressed with very high levels in adult liver and high levels in adult lung. According to PubMed:10428057 expressed at low levels in liver. Expressed at increased levels in atherosclerotic lesions observed in hyperhomocysteinema.
PMID: 8673705 by Park C.G., et al. A novel gene product that couples TCR signaling to Fas(CD95) expression in activation-induced cell death.
PMID: 10428057 by Gomes I., et al. A proline- and glutamine-rich protein promotes apoptosis in neuronal cells.