Prohibitin-2 Antibodies

AND PHB2 ELISA kits, Prohibitin-2 Proteins

Many biological assays use antibodies to detect Prohibitin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prohibitin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prohibitin-2 antibodies...

We validate the specificity of these antibodies to Prohibitin-2 by testing them on tissues known to express PHB2 positively and negatively. Browse below to find the PHB2 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PHB2 Infographic by Boster Bio

All PHB2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-REA/PHB2 Antibody Picoband®

17 Q&As

Human, Mouse, Rat

IHC, ICC, WB

$370
Cat # PA1951
100 μg/vial

Anti-REA/PHB2 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A03315-3
100 μg/vial

Anti-REA/PHB2 Antibody Picoband® (monoclonal, 2B5)

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # M03315
100 μg/vial

Human Prohibitin 2 Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTQ99623
Starting from 20ug

Anti-REA Rabbit Monoclonal Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$370
Cat # M03315-1
100 μl/vial

Anti-Fruit fly Phb2 Antibody

Fruit fly

$470
Cat # DZ41317
200 μl/vial

PHB2 Overview

Facts about Prohibitin-2.

PHB2 3D structure. Source: alphafold

Prohibitin-2 (PHB2)

Acts as a mediator of transcriptional repression by nuclear hormone receptors through recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator which potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens.

Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

Gene Information

Human
Gene Name:	PHB2
Uniprot:	Q99623
Entrez:	11331

Family

Belongs to:

prohibitin family

Alternative Names

BAP; Bap37; BCAP37; B-cell associated protein; D-Prohibitin; MGC117268; p22; PHB2; PNAS-141; Prohibitin 2; prohibitin-2; REA; REAB-cell receptor-associated protein BAP37; Repressor of estrogen receptor activity

Molecular Weight

Mass (kDA):
33.296 kDA

Genomic Context


Human

Location:	12p13.31
Sequence:	12; NC_000012.12 (6965327..6970753, complement)

Subcellular Localizations

Mitochondrion inner membrane. Cytoplasm. Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Carcinoma
Mammary Neoplasms
Liver Carcinoma
Malignant Neoplasm Of Ovary
Infective Disorder
Cell Transformation, Neoplastic
Obesity
Follicular Cyst
Optic Atrophy
Neoplasm Metastasis

Swine Diseases
Hypoxia
Lung Diseases
Airway Obstruction
Infertility
Malignant Tumor Of Cervix
Carcinoma In Situ

Interacting Proteins

ESR1

Pathways

Cell Proliferation
Localization
Senescence
Aging
Mitochondrial Fusion
Transport
Cell Cycle
Rna Interference
Electron Transport
Proteolysis
Replicative Senescence
Cell Division
Cellular Process

Ovulation
Oxidative Phosphorylation
Cell Death
Cell Activation
T Cell Activation
Membrane Organization
Nuclear Transport

PTMs

Phosphorylation

Biotinylation

Cleavage

Research Areas

Cellular Markers
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHB2

References

PMID: 9074930 by Ansari-Lari M.A., et al. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.

PMID: 10359819 by Montano M.M., et al. An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens.