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ACOT7 Antibodies
AND ACOT7 ELISA kits, ACOT7 Proteins
Many biological assays use antibodies to detect ACOT7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ACOT7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ACOT7 antibodies...
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ACOT7 Infographic by Boster Bio
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ACOT7 Overview
Facts about Cytosolic acyl coenzyme A thioester hydrolase.
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in mind.
May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors in addition to the substrates for fatty acid metabolizing enzymes, leading to lipid homeostasis. Has broad specificity, active towards oily acyl-CoAs with chain-lengths of C8-C18.
Gene Information
| Human | |
|---|---|
| Gene Name: | ACOT7 |
| Uniprot: | O00154 |
| Entrez: | 11332 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ACH1; acyl-CoA thioesterase 7CTE-IIa; BACHEC 3.1.2.2; brain acyl CoA hydrolase; Brain acyl-CoA hydrolase; CTE-IILACH; cytosolic acyl coenzyme A thioester hydrolase; hBACH; Long chain acyl-CoA thioester hydrolase; long chain
Molecular Weight
Mass (kDA):
41.796 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.31 |
| Sequence: | 1; NC_000001.11 (6264272..6393766, complement) |
Tissue Specificity
Isoform 4 is expressed exclusively in brain.
Subcellular Localizations
[Isoform 4]: Cytoplasm, cytosol.; [Isoform 6]: Cytoplasm, cytosol.; [Isoform 1]: Mitochondrion.; [Isoform 5]: Mitochondrion.
Diseases
- Nervousness
- Epilepsy
- Inflammatory Disorder
- Neuroblastoma
- Obesity
- Inflammation
Interacting Proteins
- CAMK2B
- MAGEA6
- THAP1
- UBQLN1
Pathways
- Fatty Acid Oxidation
- Localization
- Regulation Of Fatty Acid Oxidation
- Fatty Acid Beta-oxidation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACOT7
bosterbio.com/bosterbio-gene-info-cards/ACOT7
References
PMID: 10578051 by Yamada J., et al. Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase.
PMID: 12435388 by Yamada J., et al. Human brain acyl-CoA hydrolase isoforms encoded by a single gene.