This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Peptidoglycan recognition protein 4.
May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria.
Human | |
---|---|
Gene Name: | PGLYRP4 |
Uniprot: | Q96LB8 |
Entrez: | 57115 |
Belongs to: |
---|
N-acetylmuramoyl-L-alanine amidase 2 family |
peptidoglycan recognition protein 4; peptidoglycan recognition protein I beta; Pglyrp-1 beta; PGLYRP4; PGRPI beta; PGRP-I beta; PGRP-I-beta
Mass (kDA):
40.62 kDA
Human | |
---|---|
Location: | 1q21.3 |
Sequence: | 1; NC_000001.11 (153327410..153348844, complement) |
Detected in skin epidermis, eccrine sweat glands and ducts, mucous cells in the submandibular salivary gland, mucous cells in the throat, ciliary body epithelial cells of the eye, small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). High expression in skin and esophagus. Expressed also to a much lesser extent in the tonsils and thymus.
Secreted.
PMID: 11461926 by Liu C., et al. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.
PMID: 16354652 by Lu X., et al. Peptidoglycan recognition proteins are a new class of human bactericidal proteins.