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- Table of Contents
Facts about Peptidoglycan recognition protein 3.
May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria.
Human | |
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Gene Name: | PGLYRP3 |
Uniprot: | Q96LB9 |
Entrez: | 114771 |
Belongs to: |
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N-acetylmuramoyl-L-alanine amidase 2 family |
peptidoglycan recognition protein 3; peptidoglycan recognition protein I alpha; Peptidoglycan recognition protein I-alpha; Peptidoglycan recognition protein intermediate alpha; peptidoglycan recognition protein-I-alpha; PGLYRP3; PGLYRPIalphaMGC149197; PGRP1A; PGRPI alpha; PGRP-I alpha; PGRPIA; PGRP-Ialpha; PGRPIAPGRP-I-alpha
Mass (kDA):
37.611 kDA
Human | |
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Location: | 1q21.3 |
Sequence: | 1; NC_000001.11 (153297589..153312975, complement) |
Detected in skin epidermis, eccrine sweat glands and ducts, ciliary body epithelial cells of the eye, in small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). Highly expressed in skin and esophagus, expressed also in tonsils and thymus and to a much lesser extent in the stomach, descending colon, rectum and brain.
Secreted.
PMID: 11461926 by Liu C., et al. Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.
PMID: 16354652 by Lu X., et al. Peptidoglycan recognition proteins are a new class of human bactericidal proteins.