ATP-dependent 6-phosphofructokinase, liver type (PFKL)

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species.

Upon macrophage activation, drives the metabolic change toward glycolysis, thus preventing glucose absorption that produces NADPH through pentose phosphate pathway (By similarity). .