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PEA15 Antibodies
AND PEA15 ELISA kits, PEA15 Proteins
Many biological assays use antibodies to detect PEA15, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PEA15 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PEA15 antibodies...
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PEA15 Infographic by Boster Bio
All PEA15 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1450
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1450
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2105
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2105
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2172
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2172
1 kit, containing two 96-well plates and all necessary reagents
Human, Monkey, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A02988S116
100ul
Cat # A02988S116
100ul
Human, Monkey, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A02988S104
100ul
Cat # A02988S104
100ul
PEA15 Overview
Facts about Astrocytic phosphoprotein PEA-15.
Astrocytic phosphoprotein PEA-15 (PEA15)
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity).
Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 action and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
Gene Information
| Human | |
|---|---|
| Gene Name: | PEA15 |
| Uniprot: | Q15121 |
| Entrez: | 8682 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
HMAT1; HMAT115kD; HUMMAT1H; MAT1H; PEA15; PEA-15; PED; PED15 kDa phosphoprotein enriched in astrocytes; phosphoprotein enriched in astrocytes 15; Phosphoprotein enriched in diabetes
Molecular Weight
Mass (kDA):
15.04 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.2 |
| Sequence: | 1; NC_000001.11 (160205384..160215376) |
Tissue Specificity
Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose- producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
Subcellular Localizations
Cytoplasm. Associated with microtubules.
Diseases
- Neoplasms
- Malignant Neoplasms
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Insulin Resistance
- Glioblastoma
- Glioma
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Carcinoma
- Brain Neoplasms
- Mammary Neoplasms
- Carcinogenesis
Interacting Proteins
- MAPK1
- MAPK3
- TERF2IP
Pathways
- Cell Death
- Cell Proliferation
- Localization
- Transport
- Sensitization
- Cell Growth
- Secretion
- Pathogenesis
- Cell Cycle
- Glucose Transport
- Insulin Secretion
- Senescence
- Nuclear Export
PTMs
- Phosphorylation
- Cleavage
- Reduction
- Dephosphorylation
Research Areas
- Apoptosis
- Cell Biology
- Cellular Markers
- Phospho-Specific
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PEA15
bosterbio.com/bosterbio-gene-info-cards/PEA15
References
PMID: 8662970 by Estelles A., et al. The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human.
PMID: 9670003 by Condorelli G., et al. PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.