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PDZK1 Antibodies
AND PDZK1 ELISA kits, PDZK1 Proteins
Many biological assays use antibodies to detect PDZK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDZK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDZK1 antibodies...
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PDZK1 Overview
Facts about Na(+)/H(+) exchange regulatory cofactor NHE-RF3.
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1)
A scaffold protein that connects plasma membrane proteins and regulatory elements, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse selection of regulatory processes for ion transport and second messenger cascades.
In complex with SLC9A3R1, may cluster proteins that are functionally determined in a mutual fashion and modulate the trafficking and the action of the associated membrane proteins. May potentiate the CFTR chloride channel activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | PDZK1 |
| Uniprot: | Q5T2W1 |
| Entrez: | 5174 |
Family
| Belongs to: |
|---|
| NHER family |
Alternative Names
CAP70; CFTR-associated protein of 70 kDa; CLAMP; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; NaPi-Cap1; NHERF3; NHERF-3; NHERF3PDZD1Na(+)/H(+) exchange regulatory cofactor NHE-RF3; PDZ domain containing 1; PDZ domain-containing protein 1; PDZ-containing kidney protein 1; PDZD1; PDZK1; Sodium-hydrogen exchanger regulatory factor 3
Molecular Weight
Mass (kDA):
57.129 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.1 |
| Sequence: | 1; NC_000001.11 (145670852..145708201, complement) |
Tissue Specificity
Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas.
Subcellular Localizations
Membrane; Peripheral membrane protein. Cell membrane. Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes.
Diseases
- Fibrosis
- Malignant Neoplasms
- Cystic Fibrosis
- Cardiovascular Diseases
- Neoplasms
- Atherosclerosis
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Carcinoma
- Diarrhea
- Adenoma
- Secretory Diarrhea
- Hyperuricemia
Interacting Proteins
- CFTR
Pathways
- Transport
- Localization
- Secretion
- Cholesterol Transport
- Reverse Cholesterol Transport
- Excretion
- Urate Transport
- Intestinal Absorption
- Ion Transport
- Endocytosis
- Pathogenesis
- Cell Adhesion
- Cell Migration
PTMs
- Phosphorylation
- Biotinylation
- Carboxylation
Research Areas
- Cellular Markers
- Diabetes Research
- Endothelial Cell Markers
- Growth and Development
- Lipid and Metabolism
- Neuronal Cell Markers
- Plasma Membrane Markers
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDZK1
bosterbio.com/bosterbio-gene-info-cards/PDZK1
References
PMID: 9461128 by Kocher O., et al. Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains.
PMID: 10496535 by Kocher O., et al. PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein.