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PEG3 Antibodies
AND PEG3 ELISA kits, PEG3 Proteins
Many biological assays use antibodies to detect PEG3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PEG3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PEG3 antibodies...
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PEG3 Overview
Facts about Paternally-expressed gene 3 protein.
Paternally-expressed gene 3 protein (PEG3)
Induces apoptosis in Collaboration with SIAH1A.
Acts as a mediator between p53/TP53 and BAX at a neuronal death pathway that is triggered by DNA damage.Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | PEG3 |
| Uniprot: | Q9GZU2 |
| Entrez: | 5178 |
Family
| Belongs to: |
|---|
| krueppel C2H2-type zinc-finger protein family |
Alternative Names
DKFZp781A095; KIAA0287PW1; paternally expressed 3; paternally expressed gene 3; Zinc finger and SCAN domain-containing protein 24; ZNF904; ZSCAN24Kruppel-type zinc finger protein
Molecular Weight
Mass (kDA):
180.827 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.43 |
| Sequence: | 19; NC_000019.10 (56810082..56840726, complement) |
Tissue Specificity
Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines.
Subcellular Localizations
Nucleus. Cytoplasm.
Diseases
- Benign Mixed Epithelial And Stromal Tumor Of Kidney
- Neoplasms
- Malignant Neoplasms
- Beckwith-wiedemann Syndrome
- Brain Neoplasms
- Hydatidiform Mole
- Russell-silver Syndrome
- Glioma
- Chimera Disorder
- Cell Transformation, Neoplastic
- Ovarian Neoplasm
- Atrophy
Pathways
- Methylation
- Dna Methylation
- Oogenesis
- Cell Death
- Cell Cycle
- Maternal Behavior
- Spermatogenesis
- Oocyte Growth
- Fertilization
- Mating
- Mitosis
- Localization
- Demethylation
PTMs
- Methylation
- Demethylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PEG3
bosterbio.com/bosterbio-gene-info-cards/PEG3
References
PMID: 11677152 by Van den Veyver I.B., et al. The human homologue (PEG3) of the mouse paternally expressed gene 3 (Peg3) is maternally imprinted but not mutated in women with familial recurrent hydatidiform molar pregnancies.
PMID: 11331620 by Hiby S.E., et al. Paternal monoallelic expression of PEG3 in the human placenta.