PDZD3 Antibodies

AND PDZD3 ELISA kits, PDZD3 Proteins

Many biological assays use antibodies to detect PDZD3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDZD3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDZD3 antibodies...

We validate the specificity of these antibodies to PDZD3 by testing them on tissues known to express PDZD3 positively and negatively. Browse below to find the PDZD3 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PDZD3 Infographic by Boster Bio

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PDZD3 Overview

Facts about Na(+)/H(+) exchange regulatory cofactor NHE-RF4.

PDZD3 3D structure. Source: alphafold

Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (PDZD3)

Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).

Gene Information

Human
Gene Name:	PDZD3
Uniprot:	Q86UT5
Entrez:	79849

Family

Belongs to:

No superfamily

Alternative Names

FLJ22756; IKEPPPDZK2; intestinal and kidney enriched PDZ protein; Intestinal and kidney-enriched PDZ protein; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Na/Pi cotransporter C-terminal-associated protein 2; naPi-Cap2; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; NHERF4; NHERF-4; PDZ domain containing 2; PDZ domain containing 3; PDZ domain-containing protein 2; PDZ domain-containing protein 3; Sodium-hydrogen exchanger regulatory factor 4

Molecular Weight

Mass (kDA):
61.032 kDA

Genomic Context


Human

Location:	11q23.3
Sequence:	11; NC_000011.10 (119185457..119190218)

Subcellular Localizations

Cell membrane; Peripheral membrane protein. Cytoplasm. Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451).

Interacting Proteins

ASAP3
CACNA1S
GUCY2C
SLC41A3
SPRYD7

Research Areas

Lipid and Metabolism
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDZD3

References

PMID: 11950846 by Scott R.O., et al. A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor.

PMID: 19088451 by Zachos N.C., et al. Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.