This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
PDLIM4 Antibodies
AND PDLIM4 ELISA kits, PDLIM4 Proteins
Many biological assays use antibodies to detect PDLIM4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDLIM4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDLIM4 antibodies...
Previous: CBLIF
Next: PRKRA
PDLIM4 Infographic by Boster Bio
All PDLIM4 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A09573-2
100 μg/vial
Cat # A09573-2
100 μg/vial
PDLIM4 Overview
Facts about PDZ and LIM domain protein 4.
PDZ and LIM domain protein 4 (PDLIM4)
Isoform 1: Suppresses SRC activation by recognizing and binding to active SRC and easing PTPN13-mediated dephosphorylation of SRC'Tyr-419' leading to its inactivation. Involved in reorganization of the actin cytoskeleton (PubMed:21636573).
In nonmuscle cells, binds to ACTN1 (alpha- actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transfer in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane.
Gene Information
| Human | |
|---|---|
| Gene Name: | PDLIM4 |
| Uniprot: | P50479 |
| Entrez: | 8572 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
LIM domain protein; LIM protein RIL; PDZ and LIM domain 4; PDZ and LIM domain protein 4; Reversion-induced LIM protein; RILenigma homolog
Molecular Weight
Mass (kDA):
35.398 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q31.1 |
| Sequence: | 5; NC_000005.10 (132257658..132273454) |
Tissue Specificity
Isoform 2 is found in brain.
Subcellular Localizations
[Isoform 1]: Cytoplasm, cytoskeleton. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, dendritic spine. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome. Localizes to actin stress fibers in nonmuscle cells. Colocalizes with GRIA1 in early endosomes. Enriched in numerous but not all spine-like structures along dendritic branches. Colocalizes with actin and enriched at sites containing larger amounts of actin and
Diseases
- Malignant Neoplasms
- Neoplasms
- Prostatic Neoplasms
- Carcinoma
- Malignant Neoplasm Of Prostate
- Leukemia
- Myeloid Leukemia
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Prostatic Hyperplasia
- Malignant Paraganglionic Neoplasm
Pathways
- Methylation
- Dna Methylation
- Cell Growth
- Localization
- Demethylation
- Cell Motility
- Cell Proliferation
- Gene Silencing
- Dna Hypermethylation
- G1 Phase
PTMs
- Methylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDLIM4
bosterbio.com/bosterbio-gene-info-cards/PDLIM4
References
PMID: 9573374 by Bashirova A.A., et al. The human RIL gene: mapping to human chromosome 5q31.1, genomic organization and alternative transcripts.
PMID: 10826496 by Cuppen E., et al. The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL.