PDE8B Antibodies

AND PDE8B ELISA kits, PDE8B Proteins

Many biological assays use antibodies to detect PDE8B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE8B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE8B antibodies...

We validate the specificity of these antibodies to PDE8B by testing them on tissues known to express PDE8B positively and negatively. Browse below to find the PDE8B antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PDE8B Infographic by Boster Bio

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PDE8B (NM_001029853) Human Over-expression Lysate

Human

$960
Cat # LS008622
100 µg

PDE8B Overview

Facts about High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B.

PDE8B 3D structure. Source: alphafold

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B)

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.

Gene Information

Human
Gene Name:	PDE8B
Uniprot:	O95263
Entrez:	8622

Family

Belongs to:

cyclic nucleotide phosphodiesterase family

Alternative Names

3'-5' cyclic nucleotide phosphodiesterase 8B; ADSD; Cell proliferation-inducing gene 22 protein; EC 3.1.4.17; FLJ11212; high affinity cAMP-specific and IBMX-insensitive 3'-5'-cyclic phosphodiesterase8B; hsPDE8B; phosphodiesterase 8B; PPNAD3

Molecular Weight

Mass (kDA):
98.979 kDA

Genomic Context


Human

Location:	5q13.3
Sequence:	5; NC_000005.10 (77180304..77428256)

Tissue Specificity

Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates.

Diseases

Neoplasms
Cushing Syndrome
Hyperplasia
Adrenal Hyperplasia
Tumors Of Adrenal Cortex
Carney Complex
Adenoma
Congenital Adrenal Hyperplasia
Adrenal Cortical Adenoma
Pituitary Diseases
Hypothyroidism
Alzheimer's Disease
Depressive Disorder

Cell Transformation, Neoplastic
Adrenal Cortical Hyperplasia
Malignant Neoplasms
Acute Interstitial Pneumonia
Major Depressive Disorder
Endocrine Gland Neoplasms
Insulinoma

Pathways

Secretion
Insulin Secretion
Methylation
Cell Cycle
Dna Methylation
Hypersensitivity
Exocytosis
Cortisol Secretion

Localization
Hormone Secretion

PTMs

Phosphorylation

Methylation

Research Areas

Lipid and Metabolism
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE8B

References

PMID: 12372422 by Hayashi M., et al. Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene.

PMID: 12681444 by Gamanuma M., et al. Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans.