PDE2A Antibodies

AND PDE2A ELISA kits, PDE2A Proteins

Many biological assays use antibodies to detect PDE2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE2A antibodies...

We validate the specificity of these antibodies to PDE2A by testing them on tissues known to express PDE2A positively and negatively. Browse below to find the PDE2A antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PDE2A Infographic by Boster Bio

All PDE2A Products

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Product

Figures

Specificity

Applications

Price

Anti-PDE2A Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A03472
100ul

Anti-PDE2A Mouse Monoclonal Antibody [Clone ID: OTI1G9]

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$523
Cat # M03472
100 µl

Anti-PDE2A Mouse Monoclonal Antibody [Clone ID: OTI3A4]

Human, Mouse, Rat

Flow Cytometry, IF, IHC, WB

$523
Cat # M03472-1
100 µl

Anti-PDE2A Rabbit Monoclonal Antibody

Human, Mouse, Rat

$370
Cat # M03472-2
100 μl/vial

PDE2A (NM_002599) Human Over-expression Lysate

Human

$628
Cat # LS005138
100 µg

PDE2A Overview

Facts about cGMP-dependent 3',5'-cyclic phosphodiesterase.

PDE2A 3D structure. Source: alphafold

cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A)

Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an essential role in growth and invasion of malignant melanoma cells (e.

g. pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027).

Gene Information

Human
Gene Name:	PDE2A
Uniprot:	O00408
Entrez:	5138

Family

Belongs to:

cyclic nucleotide phosphodiesterase family

Alternative Names

cGMP-dependent 3'-5'-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 4; cGSPDE; CGS-PDE; Cyclic GMP-stimulated phosphodiesterase; EC 3.1.4; EC 3.1.4.17; PDE2A1; PED2A4; phosphodiesterase 2A, cGMP-stimulated

Molecular Weight

Mass (kDA):
105.717 kDA

Genomic Context


Human

Location:	11q13.4
Sequence:	11; NC_000011.10 (72576140..72674422, complement)

Tissue Specificity

Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.

Subcellular Localizations

[Isoform PDE2A3]: Cell membrane; Lipid-anchor.; [Isoform PDE2A2]: Mitochondrion matrix. Mitochondrion inner membrane. Mitochondrion outer membrane.; [Isoform PDE2A1]: Cytoplasm.; [Isoform 5]: Mitochondrion.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Tumor Angiogenesis
Erectile Dysfunction
Infectious Mononucleosis
Globus Hystericus
Pathologic Neovascularization
African Trypanosomiasis
Lung Injury
Ventilator-induced Lung Injury
Edema
Tissue Adhesions

Systemic Infection
Adenoma
Neoplasm Metastasis
Varicosity
Malignant Neoplasm Of Breast
Glioma
Respiration Disorders

Interacting Proteins

Pathways

Localization
Cell Cycle
Angiogenesis
Cell Proliferation
Cell Death
Transport
Protein Phosphorylation
Cell Adhesion
Cell Migration
Aging
Muscle Contraction
Platelet Activation
Virulence

Membrane Biogenesis
Endothelial Cell Proliferation
Platelet Aggregation
Cell Division
Reverse Transcription
Translation
Phototransduction

PTMs

Phosphorylation
Biotinylation

Acylation
Palmitoylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE2A

References

PMID: 9210593 by Rosman G.J., et al. Isolation and characterization of human cDNAs encoding a cGMP- stimulated 3',5'-cyclic nucleotide phosphodiesterase.

PMID: 19632989 by Russwurm C., et al. Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes.