PCSK7 Antibodies

AND PCSK7 ELISA kits, PCSK7 Proteins

Many biological assays use antibodies to detect PCSK7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PCSK7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PCSK7 antibodies...

We validate the specificity of these antibodies to PCSK7 by testing them on tissues known to express PCSK7 positively and negatively. Browse below to find the PCSK7 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PCSK7 Infographic by Boster Bio

All PCSK7 Products

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Product

Figures

Specificity

Applications

Price

Anti-PCSK7 Mouse Monoclonal Antibody [Clone ID: OTI1B8]

Human, Mouse, Rat

Flow Cytometry, IF

$523
Cat # M06686
100 µl

PCSK7 (NM_004716) Human Over-expression Lysate

Human

$628
Cat # LS009159
100 µg

PCSK7 Overview

Facts about Proprotein convertase subtilisin/kexin type 7.

PCSK7 3D structure. Source: alphafold

Proprotein convertase subtilisin/kexin type 7 (PCSK7)

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Probably functions in the constitutive secretory pathway.

Gene Information

Human
Gene Name:	PCSK7
Uniprot:	Q16549
Entrez:	9159

Family

Belongs to:

peptidase S8 family

Alternative Names

EC 3.4.21; EC 3.4.21.-; EC 3.4.21.61; EC 3.4.21.75; EC 3.4.21.93; hPC8; LPC; LPCFLJ23503; Lymphoma proprotein convertase; PC7FLJ45329; PC8prohormone convertase PC7; PCSK7; Prohormone convertase 7; Proprotein Convertase 7; Proprotein convertase 8; proprotein convertase subtilisin/kexin type 7; SPC7; SPC7proprotein convertase PC7; Subtilisin/kexin-like protease PC7

Molecular Weight

Mass (kDA):
86.247 kDA

Genomic Context


Human

Location:	11q23.3
Sequence:	11; NC_000011.10 (117201156..117232525, complement)

Tissue Specificity

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte.

Subcellular Localizations

Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Seems to be localized intracellularly to the trans Golgi network.

Diseases

Lymphoma
Hiv Infections
Influenza In Birds
Immunologic Deficiency Syndromes
Tumor Angiogenesis
Malignant Neoplasms
Neoplasms
Pituitary Diseases
Influenza
Tissue Adhesions
Neoplasm Metastasis
Coronary Heart Disease

Tumor Progression
Malignant Tumor Of Colon
Endometrial Polyp
Carcinoma
Headache
Hyperlipoproteinemia Type Iia

Pathways

Localization
Secretory Pathway
Ovarian Follicle Development
Zymogen Activation
Lymphangiogenesis
Angiogenesis
Secretion
Cell Adhesion
Clathrin-mediated Endocytosis
Constitutive Secretory Pathway
Virus Maturation
Fertilization
Endocytosis

Ovulation
Tropism
Decidualization
Menstruation
Reverse Transcription
Dentinogenesis
Acrosome Reaction

PTMs

Cleavage
Phosphorylation
Palmitoylation

Reduction
Glycosylation
Amidation

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PCSK7

References

PMID: 8615762 by Bruzzaniti A., et al. PC8, a new member of the convertase family.

PMID: 8564950 by Meerabux J., et al. A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas.