PCSK2 Antibodies

AND PCSK2 ELISA kits, PCSK2 Proteins

Many biological assays use antibodies to detect PCSK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PCSK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PCSK2 antibodies...

We validate the specificity of these antibodies to PCSK2 by testing them on tissues known to express PCSK2 positively and negatively. Browse below to find the PCSK2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PCSK2 Infographic by Boster Bio

All PCSK2 Products

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Proprotein Convertase 2 (PCSK2) (NM_002594) Human Recombinant Protein

$813
Cat # PROTP16519
20 µg

Proprotein Convertase 2 (PCSK2) (NM_002594) Human Over-expression Lysate

Human

$960
Cat # LS005126
100 µg

PCSK2 Overview

Facts about Neuroendocrine convertase 2.

PCSK2 3D structure. Source: alphafold

Neuroendocrine convertase 2 (PCSK2)

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.

Gene Information

Human
Gene Name:	PCSK2
Uniprot:	P16519
Entrez:	5126

Family

Belongs to:

peptidase S8 family

Alternative Names

EC 3.4.21; EC 3.4.21.94; KEX2-like endoprotease 2; NEC 2; NEC2; NEC2SPC2; neuroendocrine convertase 2; PC2; PC2NEC-2; PCSK2; Prohormone convertase 2; Proprotein Convertase 2; proprotein convertase subtilisin/kexin type 2; SPC2

Molecular Weight

Mass (kDA):
70.565 kDA

Genomic Context


Human

Location:	20p12.1
Sequence:	20; NC_000020.11 (17226107..17484578)

Subcellular Localizations

Cytoplasmic vesicle, secretory vesicle. Secreted. Localized in the secretion granules.

Diseases

Malignant Neoplasms
Neoplasms
Thyroid Neoplasm
Diabetes Mellitus, Non-insulin-dependent
Malignant Neoplasm Of Thyroid
Malignant Paraganglionic Neoplasm
Diabetes Mellitus
Obesity
Adenoma
Carcinoma
Pituitary Diseases
Follicular Adenoma
Follicular Thyroid Carcinoma

Thyroid Nodule
Vaccinia
Inflammation
Carcinoma, Papillary
Insulin Resistance
Cardiovascular Diseases
Papillary Thyroid Carcinoma

Pathways

Secretion
Insulin Secretion
Cell Proliferation
Cell Differentiation
Pathogenesis
Glucagon Secretion
Secretory Pathway
Lactation
Pancreas Development
Gene Silencing
Parturition
Cell Development
Gluconeogenesis

Energy Homeostasis
Localization
Glomerular Filtration
Glucose Homeostasis
Hatching
Regulated Secretory Pathway
Hatching Behavior

PTMs

Cleavage

Phosphorylation

Amidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PCSK2

References

PMID: 2154467 by Smeekens S.P., et al. Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

PMID: 1594602 by Ohagi S., et al. Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues.