PCNA Antibodies

AND PCNA ELISA kits, PCNA Proteins

Many biological assays use antibodies to detect PCNA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PCNA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PCNA antibodies...

We validate the specificity of these antibodies to PCNA by testing them on tissues known to express PCNA positively and negatively. Browse below to find the PCNA antibody that suites your experiment. We have 8 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PCNA Infographic by Boster Bio

All PCNA Products

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Product

Figures

Specificity

Applications

Price

Anti-PCNA Antibody (Monoclonal, PC 10)

131 Citations 17 Q&As

Human, Mouse, Rat

IHC, ICC, WB

$370
Cat # MA1083
100 μg/vial

Anti-PCNA (Proliferating Cell Nuclear Antigen) (G1- & S-phase Marker) Monoclonal Antibody

72 Citations 14 Q&As

Chicken, Drosophila, Human, Monkey, Mouse, Pig, Rat, Yeast, Zebrafish

Flow Cytometry, IF, IHC, WB

$486
Cat # M00125
100ug/vial

Anti-PCNA Rabbit Monoclonal Antibody

63 Citations 16 Q&As

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M00125-1
100 μl

Anti-PCNA Antibody Picoband®

60 Citations 5 Q&As

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A00125
100 μg/vial

Human PCNA Recombinant Protein

SDS-PAGE

$250
Cat # PROTP12004
Starting from 20ug

Anti-PCNA Antibody

Human

Flow Cytometry, IHC-P, WB

$299
Cat # M00125-2
50 µl

Anti-PCNA Antibody Picoband® (monoclonal, 2G2)

24 Citations

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M00125-3
100 μg/vial

PCNA (NM_002592) Human Over-expression Lysate

Human

$628
Cat # LS005111
100 µg

PCNA Overview

Facts about Proliferating cell nuclear antigen.

Proliferating cell nuclear antigen (PCNA)

Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities.

Must be loaded onto DNA in order to be able to stimulate APEX2. Plays a vital role in DNA damage response (DDR) by being conveniently positioned in the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902).

Gene Information

Human
Gene Name:	PCNA
Uniprot:	P12004
Entrez:	5111

Family

Belongs to:

PCNA family

Alternative Names

cyclin; DNA polymerase delta auxiliary protein; MGC8367; proliferating cell nuclear antigen

Molecular Weight

Mass (kDA):
28.769 kDA

Genomic Context


Human

Location:	20p12.3
Sequence:	20; NC_000020.11 (5114953..5126622, complement)

Subcellular Localizations

Nucleus. Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.

Diseases

Neoplasms
Malignant Neoplasms
Carcinoma
Hyperplasia
Malignant Paraganglionic Neoplasm
Neoplasm Metastasis
Malignant Squamous Cell Neoplasm
Carcinogenesis
Adenocarcinoma
Cell Transformation, Neoplastic
Malignant Neoplasm Of Breast
Cell Invasion
Mammary Neoplasms

Liver Carcinoma
Liver Neoplasms
Inflammation
Dysplasia
Tumor Angiogenesis
Lung Neoplasms
Liver Regeneration Disorder

Interacting Proteins

ALDOA
ANG
ANXA2
B2M
CDKN1A

CDKN2A
CDT1
CHAF1A
DDIT4L
EEF1A1

ENO1
FEN1
Gadd45g
GAPDH
HLTF

ING2
MAF1
MSH3
NCR2
PCLAF

PGAM1
PGK1
POLD1
POLD2
POLD3

POLD4
PRDX6
RNF7
SETD3
TMEM218

TPI1
ZRANB3

Pathways

Cell Proliferation
Cell Cycle
Dna Replication
S Phase
Regeneration
Dna Repair
Localization
Cell Growth
Cell Death
Angiogenesis
Pathogenesis
Cell Cycle Arrest
Liver Regeneration

Mitosis
Cell Differentiation
Secretion
Cell Division
Translesion Synthesis
G1 Phase
Epithelial Cell Proliferation

PTMs

Phosphorylation
Cleavage
Ubiquitination
Methylation
Sumoylation
Acetylation
Dephosphorylation
Reduction
Oxidation
Biotinylation

Deacetylation
Demethylation
Glycosylation
Phosphorothioation
Nitration
Ribosylation
Deamination
Hydroxylation
Carboxylation
Farnesylation

Research Areas

Autophagy
Base Excision Repair
Cellular Markers
DNA Repair
Loading Controls

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PCNA

References

PMID: 2882507 by Almendral J.M., et al. Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins.

PMID: 2565339 by Travali S., et al. Structure of the human gene for the proliferating cell nuclear antigen.

171 Publications of Boster PCNA Antibodies & ELISA Kits

PubMed ID: 10.7150/jca.49560, Down-regulation of ACACA suppresses the malignant progression of Prostate Cancer...
PubMed ID: 10.3892/or.16.5.1021, Histological type of oncogenity and expression of cell cycle genes in tumor cell...
PubMed ID: 10.3892/ol.2014.1803, Abscopal antitumor immune effects of magnet‑mediated hyperthermia at a high th...
PubMed ID: 10.3748/wjg.v13.i18.2615, Pancreas duodenal homeobox-1 expression and significance in pancreatic cancer
PubMed ID: 10.3390/ani10040631, Dietary Puerarin Supplementation Alleviates Oxidative Stress in the Small Intest...
PubMed ID: 10.2527/jas.2014-8230, Oral administration of putrescine and proline during the suckling period improve...
PubMed ID: 10.24272/j.issn.2095-8137.2020.375, LIN28A inhibits DUSP family phosphatases and activates MAPK signaling pathway to...
PubMed ID: 10.2147/CMAR.S302084, Grape Seed Proanthocyanidins (GSPs) Inhibit the Development of Cutaneous Squamou...
PubMed ID: 10.1186/1756-9966-27-60, Thalidomide influences growth and vasculogenic mimicry channel formation in mela...
PubMed ID: 10.1155/2013/905715, The Effects of High-Dose Qinggan Huoxue Recipe on Acute Liver Failure Induced by...
PubMed ID: 10.1111/j.1872-034X.2008.00456.x, Differential expression of the genes involved in amino acids and nitrogen metabo...
PubMed ID: 10.1111/j.1601-0825.2010.01655.x, Synthetic radiation‐inducible promoters mediated HSV‐TK/GCV gene therapy in ...
PubMed ID: 10.1111/j.1600-0714.2008.00728.x, Increased expression of focal adhesion kinase correlates with cellular prolifera...
PubMed ID: 10.1111/j.1478-3231.2008.01855.x, Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injur...
PubMed ID: 10.1097/CEJ.0b013e32833ebaa0, Downregulation of Id1 by small interfering RNA in prostate cancer PC3 cells in v...
PubMed ID: 10.1089/scd.2021.0100, Human Exosomes Accelerate Cutaneous Wound Healing by Promoting Collagen Synthesi...
PubMed ID: 10.1080/02713683.2019.1657463, The Evaluation of TUNEL, PCNA and SOX2 Expressions in Lens Epithelial Cells of C...
PubMed ID: 10.1042/BA20100038, Tumstatin45‐132‐TNFα suppresses tumour growth through anti‐angiogenic eff...
PubMed ID: 10.1039/D1MO00387A, 1H-NMR based metabolic study of MMTV-PyMT mice along with pathological progress ...
PubMed ID: 10.1039/C5RA22371G, Reparative activity of costunolide and dehydrocostus in a mouse model of 5-fluor...
PubMed ID: 10.1038/srep20046, Involvement of MicroRNA-210 Demethylation in Steroid-associated Osteonecrosis of...

*Showing only the more recent 20. More publications can be found for each product on its corresponding product page