This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Pericentriolar material 1 protein.
Required to anchor microtubules into the centrosome. Involved in the biogenesis of cilia.
Human | |
---|---|
Gene Name: | PCM1 |
Uniprot: | Q15154 |
Entrez: | 5108 |
Belongs to: |
---|
PCM1 family |
hPCM-1; pericentriolar material 1 protein; pericentriolar material 1; PTC4PCM-1
Mass (kDA):
228.544 kDA
Human | |
---|---|
Location: | 8p22 |
Sequence: | 8; NC_000008.11 (17922784..18029948) |
Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid.
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Recruitment to the centrosome requires microtubules and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase. Displaced from centriolar satellites and centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a proc
PMID: 8120099 by Balczon R., et al. PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution.
PMID: 10980597 by Corvi R., et al. RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma.