Pcgf5 Antibodies

AND Pcgf5 ELISA kits, Pcgf5 Proteins

Many biological assays use antibodies to detect Pcgf5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pcgf5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pcgf5 antibodies...

We validate the specificity of these antibodies to Pcgf5 by testing them on tissues known to express Pcgf5 positively and negatively. Browse below to find the Pcgf5 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Pcgf5 Infographic by Boster Bio

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PCGF5 (NM_032373) Human Over-expression Lysate

Human

$628
Cat # LS084333
100 µg

Pcgf5 Overview

Facts about Polycomb group RING finger protein 5.

Polycomb group RING finger protein 5 (Pcgf5)

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex course necessary to maintain the transcriptionally repressive state of many genes, including Hox genes, during development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:27136092, PubMed:28596365).

Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A'Lys-119' on the X chromosome and is required for normal silencing of a single copy of the X chromosome in XX females (PubMed:28596365).

Gene Information

Mouse
Gene Name:	Pcgf5
Uniprot:	Q3UK78
Entrez:	76073

Family

Belongs to:

No superfamily

Alternative Names

MGC16202; polycomb group ring finger 5; polycomb group RING finger protein 5; ring finger protein (C3HC4 type) 159; RING finger protein 159; RNF159

Molecular Weight

Mass (kDA):
29.657 kDA

Genomic Context


Mouse

Location:	19\|19 C2
Sequence:	19;

Tissue Specificity

Detected in hematopoietic stem cells and multipotent progenitor cells.

Diseases

Ehrlichiosis Chafeensis (diagnosis)

Pathways

Tropism
Actin Cytoskeleton Organization
Cytoskeleton Organization

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pcgf5

References

PMID: 27136092 by Si S., et al. Loss of Pcgf5 affects global H2A monoubiquitination but not the function of hematopoietic stem and progenitor cells.

PMID: 28596365 by Almeida M., et al. PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation.