Protein polybromo-1 Antibodies

AND PBRM1 ELISA kits, Protein polybromo-1 Proteins

Many biological assays use antibodies to detect Protein polybromo-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein polybromo-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein polybromo-1 antibodies...

We validate the specificity of these antibodies to Protein polybromo-1 by testing them on tissues known to express PBRM1 positively and negatively. Browse below to find the PBRM1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PBRM1 Infographic by Boster Bio

All PBRM1 Products

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Product

Figures

Specificity

Applications

Price

Anti-PBRM1 Rabbit Monoclonal Antibody

6 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M01130
100 μl

Anti-Protein polybromo-1 PBRM1 Antibody

Human, Mouse, Rat

$405
Cat # A01130
100ul

Anti-PBRM1 Antibody

Human

$299
Cat # M01130-2
50 µl

Anti-PBRM1 Antibody (C-term)

Human, Mouse

$299
Cat # M01130-1
80 µl

PBRM1 Overview

Facts about Protein polybromo-1.

PBRM1 3D structure. Source: alphafold

Protein polybromo-1 (PBRM1)

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of this SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF).

Acts as a negative regulator of cell proliferation. .

Gene Information

Human
Gene Name:	PBRM1
Uniprot:	Q86U86
Entrez:	55193

Family

Belongs to:

No superfamily

Alternative Names

BAF180PB1BRG1-associated factor 180; hPB1; MGC156155; MGC156156; polybromo 1; polybromo-1D; protein polybromo-1

Molecular Weight

Mass (kDA):
192.948 kDA

Genomic Context


Human

Location:	3p21.1
Sequence:	3; NC_000003.12 (52545367..52685913, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Renal Cell Carcinoma
Carcinoma
Kidney Neoplasm
Von Hippel-lindau Syndrome
Malignant Neoplasm Of Kidney
Conventional (clear Cell) Renal Cell Carcinoma
Malignant Neoplasm Of Breast
Malignant Paraganglionic Neoplasm
Pancreatic Neoplasm
Bipolar Disorder
Cell Transformation, Neoplastic

Schizophrenia
Inflammation
Mood Disorders
Malignant Neoplasm Of Pancreas
Neoplasm Metastasis
Tumor Angiogenesis
Pituitary Diseases

Interacting Proteins

ARID2
CHD7
SMARCA4

Pathways

Chromatin Remodeling
Methylation
Atp-dependent Chromatin Remodeling
Cell Proliferation
Mitosis
Senescence
Cell Cycle
Histone Acetylation
Pathogenesis
Osteoblast Differentiation
Cellular Senescence
Cell Development
Aging

Regulation Of Gene Expression
Histone Deubiquitination
Localization
Replicative Senescence
Nucleosome Assembly
Cell Growth
Angiogenesis

PTMs

Acetylation

Methylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PBRM1

References

PMID: 11078522 by Xue Y., et al. The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.

PMID: 12487023 by Horikawa I., et al. cDNA cloning of the human polybromo-1 gene on chromosome 3p21.