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PAWR Antibodies
AND PAWR ELISA kits, PAWR Proteins
Many biological assays use antibodies to detect PAWR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PAWR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PAWR antibodies...
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PAWR Infographic by Boster Bio
All PAWR Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$360
Cat # A03637
100 µl
Cat # A03637
100 µl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1485
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1485
1 kit, containing one 96-well plate and all necessary reagents
Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03637-1
100 μg/vial
Cat # A03637-1
100 μg/vial
PAWR Overview
Facts about PRKC apoptosis WT1 regulator protein.
PRKC apoptosis WT1 regulator protein (PAWR)
Pro-apoptopic protein capable of inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity.
Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 through its interaction with WT1.
Gene Information
| Human | |
|---|---|
| Gene Name: | PAWR |
| Uniprot: | Q96IZ0 |
| Entrez: | 5074 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Par-4; PAR4prostate apoptosis response protein 4; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; Prostate apoptosis response 4 protein; prostate apoptosis response protein PAR-4; transcriptional repressor PAR4; WT1-interacting protein
Molecular Weight
Mass (kDA):
36.568 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q21.2 |
| Sequence: | 12; NC_000012.12 (79584874..79691097, complement) |
Tissue Specificity
Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.
Subcellular Localizations
Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies.
Diseases
- Neoplasms
- Malignant Neoplasms
- Schizophrenia
- Sarcoma
- Dyskinetic Syndrome
- Glaucoma
- Major Depressive Disorder
- Depressive Disorder
- Lingual-facial-buccal Dyskinesia
- Leukemia
- Social Phobia
- Melanoma
- Malignant Neoplasm Of Breast
Interacting Proteins
- E2F1
- HSPA5
- SPSB1
- Spsb1
- Spsb2
- Spsb4
- VIM
Pathways
- Cell Death
- Programmed Cell Death
- Methylation
- Gland Morphogenesis
- Cell Proliferation
- Induction Of Apoptosis
- Mammary Gland Morphogenesis
- Dna Methylation
- Localization
- Demethylation
- Cellular Localization
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAWR
bosterbio.com/bosterbio-gene-info-cards/PAWR
References
PMID: 8943350 by Johnstone R.W., et al. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1.
PMID: 12242017 by Hsu S.-C., et al. Structural and functional characterization of the upstream regulatory region of the human gene encoding prostate apoptosis response factor- 4.