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PAPSS1 Antibodies
AND PAPSS1 ELISA kits, PAPSS1 Proteins
Many biological assays use antibodies to detect PAPSS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PAPSS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PAPSS1 antibodies...
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PAPSS1 Overview
Facts about Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1.
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1)
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase).
In mammals, PAPS is the sole source of sulfate; APS seems to be an intermediate in the sulfate- activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487).
Gene Information
| Human | |
|---|---|
| Gene Name: | PAPSS1 |
| Uniprot: | O43252 |
| Entrez: | 9061 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
3'-phosphoadenosine 5'-phosphosulfate synthase 1; ATPSK1SK 1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; EC 2.7.1.25; PAPS synthase 1; PAPSS 1; PAPSS3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1; SK1; Sulfurylase kinase 1
Molecular Weight
Mass (kDA):
70.833 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q25 |
| Sequence: | 4; NC_000004.12 (107613666..107720234, complement) |
Tissue Specificity
Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage.
Diseases
- Polyendocrinopathies, Autoimmune
- Dysplasia
- Retroviridae Infections
- Carcinoma
- Neoplasms
- Neoplasm Metastasis
- Colonic Neoplasms
- Endometrial Neoplasms
- Malignant Tumor Of Colon
- Endometrial Polyp
- Hepatitis B
- Degenerative Polyarthritis
Pathways
- Sulfation
- Conjugation
- Localization
- Cell Proliferation
- Regulation Of Cell Proliferation
- Cell Growth
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAPSS1
bosterbio.com/bosterbio-gene-info-cards/PAPSS1
References
PMID: 9576487 by Girard J.-P., et al. Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase.
PMID: 9668121 by Venkatachalam K.V., et al. Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domains.