PAN2-PAN3 deadenylation complex subunit Pan3 (Pan3)

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complicated, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP).

PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are subsequently degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and following 5'-3' exonucleolytic degradation by XRN1.