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PAK5 Antibodies
AND PAK5 ELISA kits, PAK5 Proteins
Many biological assays use antibodies to detect PAK5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PAK5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PAK5 antibodies...
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PAK5 Infographic by Boster Bio
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PAK5 Overview
Facts about Serine/threonine-protein kinase PAK 5.
Serine/threonine-protein kinase PAK 5 (PAK5)
Serine/threonine protein kinase which plays a part in a variety of different signaling pathways such as cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and another autophosphorylation on several serine and/or threonine residues.
Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD.
Gene Information
| Human | |
|---|---|
| Gene Name: | PAK5 |
| Uniprot: | Q9P286 |
| Entrez: | 57144 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
PAK5; PAK7
Molecular Weight
Mass (kDA):
80.745 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20p12.2 |
| Sequence: | 20; NC_000020.11 (9537385..9839076, complement) |
Tissue Specificity
Predominantly expressed in brain.
Subcellular Localizations
Mitochondrion. Cytoplasm. Nucleus. Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
Diseases
- Malignant Neoplasms
- Neoplasms
- Neuroblastoma
- Neoplasm Metastasis
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Nervousness
- Colorectal Cancer
- Tissue Adhesions
- Myeloid Leukemia
- Adenocarcinoma
- Colorectal Neoplasms
Interacting Proteins
- ARMC7
- ATPAF2
- CARD9
- CCNG1
- CDC42
- CRBN
- EMD
- EXOSC1
- FAM212A
- GCC1
Pathways
- Localization
- Cell Cycle
- Cell Motility
- Cell Adhesion
- Protein Phosphorylation
- Cell Proliferation
- Cell Division
- Transport
- G1 Phase
- Synaptic Transmission
- Cell Fate Determination
- Endocytosis
PTMs
Research Areas
- Breast Cancer
- Cancer
- GPCR
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAK5
bosterbio.com/bosterbio-gene-info-cards/PAK5
References
PMID: 12032833 by Pandey A., et al. Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain.
PMID: 12860998 by Ching Y.P., et al. Identification of an autoinhibitory domain of p21-activated protein kinase 5.