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PAK4 Antibodies
AND PAK4 ELISA kits, PAK4 Proteins
Many biological assays use antibodies to detect PAK4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PAK4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PAK4 antibodies...
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PAK4 Infographic by Boster Bio
All PAK4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # MP01723
100 μl
Cat # MP01723
100 μl
Human, Mouse, Rat
IHC, WB
$523
Cat # M01723
100 µl
Cat # M01723
100 µl
PAK4 Overview
Facts about Serine/threonine-protein kinase PAK 4.
Serine/threonine-protein kinase PAK 4 (PAK4)
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and another autophosphorylation on several serine and/or threonine residues.
Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Reduced cofilin activity may lead to stabilization of actin filaments.
Gene Information
| Human | |
|---|---|
| Gene Name: | PAK4 |
| Uniprot: | O96013 |
| Entrez: | 10298 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.1; KIAA1142; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A)-activated kinase 4; p21-activated kinase 4; PAK4; PAK-4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; serine/threonine-protein kinase PAK 4
Molecular Weight
Mass (kDA):
64.072 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.2 |
| Sequence: | 19; NC_000019.10 (39125786..39182816) |
Tissue Specificity
Highest expression in prostate, testis and colon.
Subcellular Localizations
Cytoplasm. Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Tissue Adhesions
- Neoplasm Invasiveness
- Cell Transformation, Neoplastic
- Carcinoma
- Liver Carcinoma
- Neoplasm Metastasis
- Prostatic Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
Interacting Proteins
- CDC42
- TERF1
- YWHAZ
Pathways
- Cell Migration
- Cell Proliferation
- Cell Motility
- Cell Death
- Cell Growth
- Cell Adhesion
- Cell Cycle
- Localization
- Rna Interference
- Nuclear Export
- Defense Response
- Pathogenesis
- Transport
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAK4
bosterbio.com/bosterbio-gene-info-cards/PAK4
References
PMID: 9822598 by Abo A., et al. PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.
PMID: 11278822 by Gnesutta N., et al. The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis.