KATNB1 Antibodies

AND KATNB1 ELISA kits, KATNB1 Proteins

Many biological assays use antibodies to detect KATNB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KATNB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KATNB1 antibodies...

We validate the specificity of these antibodies to KATNB1 by testing them on tissues known to express KATNB1 positively and negatively. Browse below to find the KATNB1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KATNB1 Infographic by Boster Bio

All KATNB1 Products

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Anti-katanin p80 (KATNB1) Mouse Monoclonal Antibody [Clone ID: OTI5C4]

Human, Mouse, Rat

Flow Cytometry, IF, IHC, WB

$523
Cat # M08144
100 µl

katanin p80 (KATNB1) (NM_005886) Human Over-expression Lysate

Human

$628
Cat # LS010300
100 µg

KATNB1 Overview

Facts about Katanin p80 WD40 repeat-containing subunit B1.

KATNB1 3D structure. Source: alphafold

Katanin p80 WD40 repeat-containing subunit B1 (KATNB1)

Participates in a complex which severs microtubules within an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of activity like the centrosome.

Microtubule severing may encourage rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome after nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, resulting in poleward microtubule flux and poleward motion of chromosome.

Gene Information

Human
Gene Name:	KATNB1
Uniprot:	Q9BVA0
Entrez:	10300

Family

Belongs to:

WD repeat KATNB1 family

Alternative Names

KAT; katanin (80 kDa); katanin p80 (WD repeat containing) subunit B 1; katanin p80 (WD40-containing) subunit B 1; Katanin p80 subunit B1; katanin p80 WD40-containing subunit B1; p80 katanin

Molecular Weight

Mass (kDA):
72.334 kDA

Genomic Context


Human

Location:	16q21
Sequence:	16; NC_000016.10 (57735770..57757244)

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles (PubMed:9658175). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214).

Diseases

Nervousness
Schizophrenia
Bipolar Disorder
Dysequilibrium Syndrome

Interacting Proteins

KATNA1
KATNAL1

Pathways

System Development
Nervous System Development

PTMs

Phosphoprotein

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KATNB1

References

PMID: 9568719 by Hartman J.J., et al. Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit.

PMID: 9658175 by McNally F.J., et al. Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs.